饮食限制延缓衰老的表观遗传学机制  

Epigenetic mechanism of dietary restriction in anti-aging

作　　者：董雯 王守安 陈秀娇 张金添 郑伟男 林心怡 DONG Wen;WANG Shou - an;CHEN Xiu - jiao;ZHANG Jin - tian;ZHENG Wei - nan;LIN Xin - yi(General Medicine Department,Putian University,Putian,Fujian 351100,China)

机构地区：[1]莆田学院基础医学部,福建莆田351100

出　　处：《现代预防医学》2018年第15期2737-2740,共4页Modern Preventive Medicine

基　　金：福建省教育厅中青年教师教育科研项目(编号:JAT170514);莆田学院校内国家基金预研项目(2017072)

摘　　要：目的近年来兴起的表观遗传学被认为在饮食影响健康、延缓衰老中发挥重要的作用。本文旨在从表观遗传学视角分析饮食限制延缓衰老的机制,为临床上抗衰老及其防治相关疾病提供理论参考。方法系统综述了表观遗传学与衰老的关系,及饮食限制延缓衰老的表观遗传调控方式。结果饮食限制通过DNA甲基化、组蛋白修饰、非编码RNA调控和染色质重塑等表观遗传修饰调节基因表达,进而影响衰老及其相关疾病的发生发展。结论饮食限制是一种有效的可操作的环境因素,可通过调节表观遗传修饰进而延缓衰老,保持健康。Objective To analyze the mechanism of DR in anti - aging from the aspect of epigenetics, and to provide a theoretical reference on delaying aging and controlling its related diseases. Methods This research systematically reviewed the relationship of epigenetics and aging, and the epigenetic regulation of diet restriction on aging. Results Dietary restriction regulated gene expression by epigenetic modification such as DNA methylation, histone modification, non- coding RNA regulation and chromatin remodeling, and then affected the development of aging and related diseases. Conclusion Dietary restriction is an effective and operable environmental factor,which can delay senility and maintain health by adjusting epigenetic modification.

关 键 词：表观遗传学 DNA甲基化 组蛋白修饰 饮食限制 衰老 

分 类 号：R15[医药卫生—营养与食品卫生学]