补体C7在非小细胞肺癌中的表达及其临床意义  

Complement C7 Expression and Clinical Significance in Non-small Cell Lung Cancer

作　　者：陈志坚[1] 吴晓宁[1] CHEN Zhijian;WU Xiaoning(The First Affiliated Hospital of Guangxi Medical University,Nanning,530021)

机构地区：[1]广西医科大学第一附属医院,530021

出　　处：《实用癌症杂志》2018年第8期1239-1241,共3页The Practical Journal of Cancer

摘　　要：目的研究补体C7在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法选取NSCLC组织标本160例,另取距离肿瘤边缘>1 cm的癌旁组织以及其他部位的正常组织各160例作为对照。检测所有标本中的C7 mRNA表达水平,并进行对比。同时对比不同病理分型以及生存期的NSCLC患者C7 mRNA表达水平。结果正常组织与癌旁组织中C7 mRNA表达水平分别为(105.4±10.4)、(67.8±8.1),均显著高于NSCLC组织的(30.4±5.6),且正常组织又显著高于癌旁组织,差异均有统计学意义(P均<0.05)。C7 mRNA在TNM分期为Ⅰ~Ⅱ期中表达水平显著高于Ⅲ~Ⅳ期,而在分化程度为1~2级中的表达水平高于分化程度为3级中,差异均有统计学意义(P均<0.05)。C7 mRNA在肿瘤复发患者中的表达水平显著低于未发生肿瘤复发患者,差异有统计学意义(P<0.05)。C7 mRNA在NSCLC生存期<15个月患者中的表达水平显著低于生存期≥15个月患者,差异有统计学意义(P<0.05)。结论补体C7在NSCLC的发生、发展中起着至关重要的作用,其表达水平的升高可促进患者病情恢复,降低复发率,同时延长生存期。Objective To study the complement C7 expression in non-small cell lung cancer（ NSCLC） and clinical significance. Methods 160 cases of NSCLC tissue specimens were enrolled as the experimental group,another take 〉 1 cm tumor edge tissue adjacent to carcinoma and normal tissue in another part of the 160 cases as the control group. C7 mRNA expression level in all specimens was detected and compared. Also compared the patients with different classification and survival period C7 mRNA expression level. Results Normal tissue and tissue adjacent to carcinoma C7 mRNA expression level were（ 105. 4 ±10. 4）,and（ 67. 8 ± 8. 1）,which were significantly higher than that of NSCLC group（ 30. 4 ± 5. 6）,and normal tissue was significantly higher than that of tissue adjacent to carcinoma,differences were statistically significant（ all P 〈 0. 05）. C7 mRNA expression in TNM staging Ⅰ ~ Ⅱ was significantly higher than Ⅲ ~ Ⅳ period,and C7 mRNA expression in differentiation 1 ~ 2 level was higher than differentiation 3 level degree,and the difference had statistical significance（ P 〈 0. 05）. C7 mRNA expression levels were significantly lower in patients with tumor recurrence than patients without tumor recurrence,the difference was statistically significant（ P 〈 0. 05）. C7 mRNA expression in NSCLC survival 〈 15 months was significantly lower than in patients with survival 〉 15 months,the difference was statistically significant（ P 〈 0. 05）. Conclusion Complement C7 in NSCLC plays an important role in occurrence and development,the rise of its expression level can promote patients recovery and reduce the recurrence rate,and prolong survival.

关 键 词：补体C7 非小细胞肺癌 表达水平 预后 

分 类 号：R734.2[医药卫生—肿瘤]