血清胃蛋白酶原联合Ca724及染色内镜对早期胃癌的诊断意义  

The Diagnostic Significance of Serum Pepsinogen Combined with Ca724 and Staining Endoscopy in Early Gastric Cancer

作　　者：郭剑 刘利平 GUO Jian;LIU Liping(Weinan Central Hospital,Weinan,714000)

机构地区：[1]陕西省渭南市中心医院,714000

出　　处：《实用癌症杂志》2018年第8期1319-1322,共4页The Practical Journal of Cancer

摘　　要：目的研究联合测定血清胃蛋白酶原(PG)、糖蛋白抗原724(Ca724)水平及染色内镜对早期胃癌的临床诊断价值。方法选取180例作为实验组,选取50例健康志愿者作为对照组,所有患者进行PGⅠ、PGⅡ、Ca724检查及染色内镜检查。结果早期胃癌患者血清PG I值降低,并且PG I/PGⅡ值降低,血清Ca724水平明显高于胃良性疾病患者和健康者(P<0.05);血清PG检查、Ca724检查及染色内镜检查三者联合检测在胃癌早期诊断中的敏感性和准确性明显高于单项检测(P<0.05)。结论采用血清胃蛋白酶原联合Ca724及染色内镜对胃早癌患者进行检查,可以提高早期胃癌临床诊断的敏感度和准确率,对胃癌的早期发现具有重要的临床诊断意义。Objective To study the diagnostic significance of serum pepsinogen（ PG）,glycoprotein antigen 724（ Ca724） level and stain endoscopy in early gastric cancer. Methods 180 cases of elderly patients with gastric mucosal lesions were selected as the experiment group. 50 cases of healthy people in medical examination center were selected as the control group. The serum PGI level,the serum PGII level,the serum PG I/PGII value,Ca724 value and dye endoscopy of the 2 groups were observed and compared. Results The serum PG I value were significantly lower and the PG I/PGII value was significantly lower than those of the control group. The serum Ca724 value were significantly higher than those of the control group and benign gastric diseases patients（ P 〈 0. 05）. The sensitivity and accuracy of pepsinogen combined with Ca724 and chromoendoscopy was significantly higher than that of the single detection（ P 〈 0. 05）. Conclusion Combined detection with pepsinogen,Ca724 and chromoendoscopy can improve the sensitivity and accuracy in the diagnosis of early gastric cancer.

关 键 词：血清胃蛋白酶原 糖蛋白抗原724 染色内镜 胃早癌 

分 类 号：R735.2[医药卫生—肿瘤]