麻醉药物及其辅助药物基因组学的研究进展  

Advances in research on pharmacogenomics of anesthetics and their adjuvants

作　　者：郑卓玲 黄民[1] 李嘉丽[1] ZHENG Zhuo-ling;HUANG Min;LI Jia-li(Institute of Clinical Pharmacology,School of Pharmaceutical Sciences,Sun Yatsen University,Guangzhou 510080,China)

机构地区：[1]中山大学药学院临床药理研究所,广东广州510080

出　　处：《中国药理学通报》2018年第8期1049-1052,共4页Chinese Pharmacological Bulletin

基　　金：国家重点研发计划项目(No 2017YFC0909303;22016YFC0905001);"十二五"国家科技重大专项资助项目(No 2012ZX09506001-004);广东省重点实验室建设项目(No 2011A060901014);广东省重大科技专项(No2011A080300001;2012A080202013)

摘　　要：麻醉药及其辅助药物是外科手术的必备药物,然而在临床常规治疗方案下,药物反应具有明显的个体差异。遗传因素是造成个体间药代动力学、药效学反应差异的重要原因。现对国内外麻醉药及其辅助药物的基因组学研究进展进行综述,为麻醉药物的个体化用药提供参考。Anesthetics and its adjuvant drugs are essential for surgery, but their drug reactions have significant individual difference in the clinical routine treatment program. Genetic polymorphism is an important influencing factor of individual differences in the pharmacokinetics and pharmacodynamics of drugs.This paper presents an overview of the research progress of pharmacogenomics of anesthetics and their adjuvant drugs at home and abroad.

关 键 词：麻醉药 药物基因组学 遗传 个体化用药 代谢酶 丙泊酚 

分 类 号：R-05[医药卫生] R394.6