MMP-2/-9裂解肌营养不良蛋白聚糖在多发性硬化/实验性自身免疫性脑脊髓炎中作用的研究进展  

MMP-2/-9 Cleavage Dystroglycan in Multiple Sclerosi/Experimental Autoimmune Encephalomyelitis

作　　者：范学慧 钟镝[1] 陈洪苹[1] 马帅男 李国忠[1] 赵秀丽[1] FAN Xue-hui;ZHONG Di;CHEN Hong-ping;MA Shuai-nan;LI Guo-zhong;ZHAO Xiu-li(The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经内科,哈尔滨150001

出　　处：《中国临床神经科学》2018年第4期451-458,共8页Chinese Journal of Clinical Neurosciences

基　　金：黑龙江省卫生厅科研课题(编号:2011-001);哈医大一院科研基金(编号:2011BS012)

摘　　要：多发性硬化(MS)是中枢神经系统炎性脱髓鞘性疾病。实验性自身免疫性脑脊髓炎(EAE)为MS的动物模型,在临床表现、神经电生理和组织病理上与MS极其相似。肌营养不良蛋白聚糖(DG)是一种非整合素家族的黏附分子,包括2个亚基:α-DG和β-DG;基质金属蛋白酶(MMP)是一种锌离子依赖的肽链内切酶。在MS/EAE中,DG的表达变化与病灶中增高的MMPs,尤其MMP-2和MMP-9有关,DG被MMP-2和MMP-9裂解参与病灶髓鞘的脱失、血脑屏障通透性增加等病理过程,文中对MS/EAE中MMP-2和MM-9对DG的作用相关研究进行综述。Multiple sclerosis（MS） is an inflammatory demyelinating disease of the central nervous system. Experimental autoimmune encephalomyelitis（EAE） is an animal model of MS with clinical manifestations, neurophysiologically and histopathologically very similar to MS. Dystroglycan（DG） is a non-integrin family of adhesion molecules, including two subunits, α-DG and β-DG, and matrix metalloproteinase（MMP） is a zinc ion-dependent endopeptidase. In MS/EAE, the expression of DG was associated with increased MMPs in the lesions, especially MMP-2 and MMP-9. The cleavage of DG by MMP-2 and MMP-9 is involved in pathological processes such as loss of myelin in lesions, increased permeability of blood-brain barrier, etc. The related researches on the effects of MMP-2 and MM-9 on DG in MS/EAE were reviewed.

关 键 词：多发性硬化 实验性自身免疫性脑脊髓炎 肌营养不良蛋白聚糖 基质金属蛋白酶-2 基质金属蛋白酶-9 

分 类 号：R744.51[医药卫生—神经病学与精神病学]