长链非编码RNA在前列腺癌中的研究进展  

Long non-coding RNAs in prostate cancer: An update

作　　者：吴品庚 张宇曦[1] WU Pin-geng;ZHANG Yu-xi(Department of Urology,The First Hospital Affiliated to China Medical University,Shenyang,Liaoning 110001,China)

机构地区：[1]中国医科大学附属第一医院泌尿外科,辽宁沈阳110001

出　　处：《中华男科学杂志》2018年第8期735-739,共5页National Journal of Andrology

基　　金：沈阳市科学技术计划(17-230-9-18);国家自然科学基金(81001143);中国前列腺癌基金会青年研究者奖~~

摘　　要：在人类基因组中存在着一类不具有编码蛋白功能且转录本长度大于200个核苷酸的RNA,称为长链非编码RNA(lncRNA)。在肿瘤领域,人们发现lncRNA的失调往往会影响恶性肿瘤的发生与进展。在前列腺癌(PCa)研究中,已有大量文献表明lncRNA的表达具有差异性,且异常表达的lncRNA可通过多种作用方式于表观遗传、转录及转录后等多水平调控基因表达,从而引起PCa细胞生物学行为改变。一些lncRNA被证明与PCa的去势抵抗性密切相关。近年,结合临床研究发现,多种lncRNA可于PCa组织、前列腺液、血清和尿液等标本中检出,且对肿瘤的放疗和化疗产生一定影响。某些lncRNA的表达还与疾病预后有关。因此,lncRNA有望成为PCa新的诊断标志物和治疗靶点。本文结合国内外研究现状,对PCa相关lncRNA的作用方式、作用机制以及其在临床应用中的潜在价值进行综述。In the human genome, there is a group of RNAs, called long non-coding RNA （lncRNA） with do not have the func- tion of encoding proteins and whose transcript length is greater than 200 nueleotides. The disorders of lncRNAs are often involved in the occurrence and progression of malignant tumors. A large number of studies have indicated the aberrant expression of lncRNAs in pros- tate cancer （PCa） can regulate gene expressions at epigenetic, transcriptional and post-transcriptional levels and cause changes in the biological behaviors of PCa cells. Some lncRNAs have been shown to be closely related to the castration resistance of PCa. In recent years, a variety of lncRNAs have been detected in the PCa tissue, prostatic fluid, serum, and urine, and somehow influenced radio- therapy and chemotherapy of tumors. The expressions of some lncRNAs are also associated with disease prognosis. Thus, lncRNAs are expected to become new diagnostic markers and a therapeutic target for PCa. This review focuses on the roles and action modes and mechanisms of some lncRNAs as well as their potential value of clinical application in the diagnosis, treatment and prognosis of PCa.

关 键 词：长链非编码RNA 前列腺癌 调控机制 肿瘤标志物 基因治疗 

分 类 号：R737.25[医药卫生—肿瘤]