遗传关联性Meta分析证据可信度评价  

Credibility assessment of meta-analysis evidence on genetic association study

作　　者：赵向 仇成凤[2,3] 史志华[3] 邓紫薇[3] 翁鸿 杨宜华 谭力铭[2,3] 曾宪涛 ZHAO Xiang;QIU Chengfeng;SHI Zhihua;DENG Ziwei;WENG Hong;YANG Yihua;TAN Liming;Z ENG Xiantao(Department of General Practice,The First People＇s Hospital of Huaihua City,Huaihua,418000,P.R.China;Department of Evidence-based Medicine and Clinical Center,The First People＇s Hospital of Huaihua City,Huaihua,418000 P.R.China;Department of Pharmacy,The First People＇s Hospital of Huaihua City,Huaihua,418000,P.R.China;Center for Evidence-Based and Translational Medicine,Zhongnan Hospital,Wuhan University,Wuhan,430071,P.R.China;School of Pharmacy,Xuzhou Medical University,Xuzhou,210004,P.R.China)

机构地区：[1]湖南省怀化市第一人民医院全科医学科,湖南怀化418000 [2]湖南省怀化市第一人民医院循证医学与临床研究中心,湖南怀化418000 [3]湖南省怀化市第一人民医院临床药学研究室,湖南怀化418000 [4]武汉大学中南医院循证与转化医学中心,武汉430071 [5]徐州医科大学药学院,江苏徐州210004

出　　处：《中国循证医学杂志》2018年第8期883-887,共5页Chinese Journal of Evidence-based Medicine

基　　金：湖南省自然科学基金项目(编号:2017JJ3250;2018JJ2307)

摘　　要：遗传关联性Meta分析将多个研究的数据整合,通过增大样本量以提高统计效能,成为探求真实遗传关联性的有效途径。Meta分析为遗传关联性证据的产生带来机遇,但同时也给此类证据的利用带来挑战。因此,合理评价证据的可信度确有必要。本文主要介绍如何使用Venice标准从分子流行病学角度评价遗传关联性Meta分析证据的可信度。评估指标包括证据量、重复性及偏倚控制三方面,最后综合三方面的分级结果,得出"强"、"中等"、"弱"三个等级结果。通过对遗传关联性Meta分析证据可信度的评估,为进一步的研究及证据的临床转化提供明确信息。Meta-analysis has become a common approach to summarize genetic association with the tremendous amount of published epidemiological evidence. Assessing the credibility of meta-analysis evidence on genetic association is a rapidly growing challenge. This paper illuminates how to assess the credibility of meta-analysis evidence by using Venice criteria. A semi-quantitative index assigns three levels for the amount of evidence, replication and protection from bias. At the end, three considerations are merged into a grading scheme, which generates three composite assessments： weak, moderate or strong. Credibility assessment is necessary to estimate whether a true genetic association exists. Such method provides indication for further study and is of dinical importance.

关 键 词：遗传关联性研究 META分析 Venice标准 可信度 

分 类 号：R-03[医药卫生]