精神分裂症患者语义加工N400成分异常及与思维形式障碍的关联研究  

Abnormal N400 activities reflecting semantic processing associated with formal thought disorder in patients with schizophrenia

作　　者：唐莺莹 赵旻骅 杨福中 乔屹[1] 钱禛颖 王继军[1] 盛建华[1] TANG Ying-ying;ZHAO Min-hua;YANG Fu-zhong;QIAO Yi;QIAN Zhen-ying;FANG Ji-jun;SHENG Jian-hua(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,200030

出　　处：《临床精神医学杂志》2018年第4期232-236,共5页Journal of Clinical Psychiatry

基　　金：上海市自然科学基金(15ZR1435500;17ZR1424700);上海市科委医学引导科技支撑项目(17411969900);上海交通大学"医工交叉研究基金"(YG2016MS36);国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873)

摘　　要：目的:探索精神分裂症患者语义加工时N400成分异常与思维形式障碍(FTD)的关系。方法:对21例伴有FTD的精神分裂症患者(SZ-FTD组)、16例不伴FTD精神分裂症患者(SZ-n FTD组)及19名健康对照者(对照组)进行语义启动任务时的脑电事件相关电位检测,分析各组在3种语义启动任务下(图片-词语一致、相关、不相关)N400波幅和潜伏期。结果:3种语义启动任务下精神分裂症患者N400波幅显著低于对照组(F(1,54)=9.60,P<0.01),潜伏期显著长于对照组(F(1,54)=4.20,P<0.05);当图片-词语不相关时,SZ-FTD组N400波幅显著低于对照组,顶区N400潜伏期显著长于对照组(P均<0.05);SZ-n FTD组与对照组N400波幅及潜伏期比较差异无统计学意义。结论:精神分裂症患者语义加工时的N400活动异常,伴有FTD的患者语义加工损害更严重。Objective： To explore the relationship of impaired semantic processing reflected by abnormal N400 component and formal thought disorder in patients with schizophrenia. Method： Twenty-one schizophrenic patients with formal thought disorder（FTD）（SZ-FTD group）,16 schizophrenia patients without FTD（SZ-n FTD group） and 19 normal controls（NC group） were recruited and participated in the picture-word semantic priming task. The event related potential component N400 was evaluated from all participants and N400 amplitudes and latencies were compared among the 3 groups across 3 conditions with the priming picture and the target word matched,related or unrelated. Results： Schizophrenia patients had significantly lower N400 amplitudes（F（1,54） = 9. 60,P〈0. 01） and longer latencies（F（1,54） = 4. 20,P〈0. 05） in all three conditions of the semantic primary task than normal controls. In the condition with the picture and target unrelated,SZ-FTD group had lower N400 amplitudes and longer N400 latencies at the top area of brain than the NC group（all P〈0. 05）; but did not differ between SZ-n FTD and NC groups. Conclusion： Schizophrenic patients have impaired semantic-related N400 activity and SZ-FTD patients may have more severe impairments of semantic processing.

关 键 词：精神分裂症 思维形式障碍 语义加工 事件相关电位N400 

分 类 号：R749.3[医药卫生—神经病学与精神病学]