双相抑郁与单相抑郁患者认知功能损害的比较  

Comparison of cognitive impairment in patients with bipolar depression and unipolar depression

作　　者：张颖[1] 李刚[1] 刘丽荣[1] 王若梅[1] ZHANG Ying;LI Gang;LIU Li-rong;FANG Ruo-mei(Tianjin Anding Hospital,Tianjin 300222,China)

机构地区：[1]天津市安定医院,300222

出　　处：《临床精神医学杂志》2018年第4期259-262,共4页Journal of Clinical Psychiatry

摘　　要：目的:探讨双相抑郁与单相抑郁患者认知功能损害情况。方法:对61例双相抑郁患者(双相组)及59例单相抑郁发作患者(单相组)及20名健康对照者(对照组)进行威斯康星卡片分类测验(WCST)、持续操作测验(CPT)、连线测验(TMT)和Stroop色词测验(CWT),并对结果进行比较和分析。结果:WCST:双相组的错误总数、持续错误数、随机错误数明显多于单相组和对照组,完成分类数明显少于单相组和对照组(P均<0.01);双相组和单相组的正确反应数明显少于对照组(P均<0.01);单相组的错误总数、持续错误数、随机错误数均多于对照组,完成分类数少于对照组(P均<0.01)。CPT:双相组3个部分的正确反应数明显少于单相组和对照组,3个部分的错误次数明显多于单相组和对照组(P均<0.01);单相组正确反应数Ⅰ少于对照组,错误次数Ⅱ多于对照组(P均<0.01)。TMT:双相组TMT-A用时明显长于单相组和对照组(P均<0.01)。CWT:双相组色词测验A、B、C用时明显长于单相组和对照组(P均<0.01);单相组色词测验A、C用时明显长于对照组(P均<0.01)。结论:双相抑郁及单相抑郁患者均有认知功能损害;双相抑郁患者执行功能、注意功能、记忆功能和信息处理速度等认知功能损害程度更重。Objective： To investigate and compare the cognitive impairment in patients with bipolar depression and unipolar depression. Method： The Wisconsin card sorting test（WCST）,continuous performance test（CPT）,trail making test（TMT） and Stroop color word test（CWT） were adminstered in 61 patients with bipolar disorder（bipolar group） and 59 patients with unipolar depression（unipolar group） and 20 healthy controls（control group）; and the results were compared and analyzed. Results： On WCST,bipolar group showed significantly more total errors,perservative errors,random errors and less categories achieved than unipolar group and control group（all P〈0. 01）; the correct response numbers of either bipolar group or unipolar group were significantly less than those of the control group（all P〈0. 01）; the unipolar group showed significantly more total errors,perservative errors,random errors and less categories achieved than and control group（all P〈0. 01）. On CPT,bipolar group showed significantly less correct response numbers and more error numbers of all the 3 partss than those in the unipolar and the control groups（all P〈0. 01）; the correct response numbers of part I in the unipolar group was less than the control group（all P〈0. 01）; the error numbers of part II was more than the control group（all P〈0. 01）. On TMT,the time of TMT-A in the bipolar group was longer than that in either the unipolar or the control groups（all P〈0. 01）. On CWT,the time of A,B and C were significantly longer than those in either the unipolar or the control groups（all P〈0. 01）; the time of A and C in the unipolar group were significantly longer than those in the control group（all P〈0. 01）.Conclusion： The patients with either bipolar depression disorder or unipolar depression disorder have cognitive function impairments. The patients with bipolar depression demonstrate more impairments in executive function,attention function,memory function and information processi

关 键 词：双相障碍 单相抑郁 认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]