CAR-T细胞特征及在复发/难治性急性B淋巴细胞白血病中的应用  

Characteristics of CAR-T Cells and Application in Relapsed/Refractory Acute B-lymphocytic Leukemia

作　　者：刘丽萍[1] 崔景英[1] LIU Liping;CUI Jingying(Department of Hematology,Weifang People＇s Hospital,Weifang 261041,China)

机构地区：[1]潍坊市人民医院血液科,山东潍坊261041

出　　处：《医学综述》2018年第15期2937-2941,共5页Medical Recapitulate

摘　　要：具有嵌合抗原受体(CAR)的T细胞的遗传修饰和特征使不同功能的T细胞亚群可识别特定的肿瘤细胞。掺入共刺激分子或细胞因子可以使工程化的T细胞消除肿瘤细胞。近年来CAR-T细胞的设计取得了实质性进展,CAR-T细胞用于复发/难治性急性B淋巴细胞白血病的Ⅰ期临床试验已经取得初步成效,患者的完全缓解率有所提高,但是其也存在不良反应,包括间接毒性和直接毒性,这可能与不受控制的T细胞增殖、细胞因子风暴或"脱靶"效应相关。The genetic modification and characterization of T-cells with chimeric antigen receptors（ CARs） allow functionally distinct T-cell subsets to recognize specific tumor cells. The incorporation of costimulatory molecules or cytokines can enable engineered T-cells to eliminate tumor cells. In recent years,substantial progress has been made in the design of CAR-T cells,which has been applied in the phase I clinical trial of relapsed/refractory acute B-lymphocytic leukemia and has achieved good results of improved complete remission rate. CAR-T has adverse reactions too,including indirect and direct toxicity,which may be associated with uncontrolled T cell proliferation,cytokine storm or off-target effects.

关 键 词：复发/难治性急性B淋巴细胞白血病 嵌合抗原受体 细胞因子风暴 

分 类 号：R733.7[医药卫生—肿瘤]