变异链球菌双组分信号传导系统的研究进展  

Research Progress of Stress Response-related Two Component Signal Transduction Systems of Streptococcus Mutans

作　　者：赵新元 崔力 ZHAO Xin-yuan;CUI Li(Department of Endodontics,Stomatological Hospital,Southern Medical University,Guangzhou 510280,China;School of Dentistry,University of California,Los Angeles,California 90095,USA)

机构地区：[1]南方医科大学口腔医院牙体牙髓科,广东广州510280 [2]加州大学洛杉矶分校牙医学院,加州90095

出　　处：《口腔医学研究》2018年第8期815-817,共3页Journal of Oral Science Research

基　　金：广东省医学科研基金(编号:B2014411);南方医科大学口腔医院院级基金课题(编号:PY2017011)

摘　　要：龋病是一种细菌感染性疾病,变异链球菌是主要致龋菌。变异链球菌的双组分信号传导系统由膜相关组氨酸蛋白激酶和胞内反式作用因子两个基本成分组成。双组分信号传导系统可以使变异链球菌感应外界环境变化和调节内部基因表达,这对于维持细菌的生存和毒力调整有重要作用。本文就与变异链球菌应激应答密切相关的双组分信号传导系统研究现状作一综述。Streptococcus mutans （S. mutans） is considered one of the primary etiological agents of dental caries. The two component signal transduction pathways network of S. mutans is comprised of histidine protein kinase and response regulator protein. Two component systems （TCSs） enable S. mutans to sense the environments changes and regulate the expression of important genes, which are essential for the survival and virulence adjustment of S. mutans. This article comprehensively reviews the current progress of the TCSs systems closely associated with stress response of S. mutans.

关 键 词：双组分信号传导系统 应激应答 VicRK LiaRS CiaRH ComDE 

分 类 号：R781.1[医药卫生—口腔医学]