角膜缘干细胞移植和羊膜移植治疗复发翼状胬肉疗效对比  

Comparison of clinical efficacy between limbal conjunctival autograft transplant and amniotic membrane transplantation for recurrent pterygium

作　　者：伍桂军[1] 曹淑娟[2] 姜爱新[2] 谭青[1] WU Guijun;CAO Shujuan;JIANG Aixin;TAN Qing(Department of Ophthalmology,Southern Hospital of Southern Medical University,Guangzhou 510515,China;Ophthalmic Center,The First People′s Hospital in Kashgar,Kashgar 844000,China)

机构地区：[1]南方医科大学南方医院眼科,广州510515 [2]新疆喀什地区第一人民医院眼科中心,新疆喀什844000

出　　处：《新疆医科大学学报》2018年第8期964-966,970,共4页Journal of Xinjiang Medical University

基　　金：2017年广东省科技发展专项资金(纵向协同管理省市联动)项目(2017B020247003);2016年新疆维吾尔自治区青年科技项目(2016Y17)

摘　　要：目的比较在新疆喀什地区第一人民医院应用角膜缘干细胞移植和羊膜移植治疗复发翼状胬肉疗效有无差异。方法选取喀什地区第一人民医院2016年11月-2017年12月67例(67眼)复发性翼状胬肉住院治疗的患者,将其随机分为2组(角膜缘干细胞移植组和羊膜移植组)。切除复发的翼状胬肉后分别施行角膜缘干细胞移植和羊膜移植,对比2组的总有效率、复发率、平均住院日和平均住院费用。结果角膜缘干细胞移植组和羊膜移植组总有效率分别是81.82%和76.47%,复发率分别是12.12%和14.71%,差异均无统计学意义(P>0.05);2组平均住院日和平均住院费用差异均具有统计学意义(P<0.05)。角膜缘干细胞移植组比羊膜移植组住院时间短,住院费用少。结论应用角膜缘干细胞移植和羊膜移植治疗复发翼状胬肉疗效无差异。角膜缘干细胞移植手术操作简单,术后反应轻,耗费医疗资源少,可优先选择。但在无角膜缘干细胞可取时可选择将复发的翼状胬肉切除干净后联合羊膜移植。Objective To compare the efficacy of limbal stem cell transplantation and amniotic membrane transplantation in the treatment of recurrent pterygium in Kashgar of Xinjiang. Methods A total of 67 cases （67 eyes） hospitalized patients with recurrent pterygium from November 2016 to December 2017 were randomly divided into two groups （limbal stem cell transplantation group and amniotic membrane transplantation group）, after excision of recurrent pterygium, they were performed limbal stem cell transplantation or amniotic membrane transplantation respectively, and total effective rate, average recurrence rate, and the average hospitalization expenses of such confinement between the two group were compared. Results In the limbal stem cell transplantation group and amniotic membrane transplantation group： the total effective rate were 81.82% and 76.47% respectively, the recurrence rate was 12.12% and 14.71% respectively, both without statistically significant differences （P 〉0.05）; the average hospitalization expenses between the two groups was statistically significant （P 〈0.05）. The limbal stem cell transplantation group had shorter hospitalization time and less hospitalization cost than the amniotic membrane transplantation group. Conclusion There is no difference between limbal stem cell transplantation and amniotic membrane transplantation in the treatment of recurrent pterygium. Moreover, Limbal stem cell transplantation can be preferred due to with simple manipulation, light postoperative response and less medical resources. But in the absence of corneal limbal stem cells, the option is to remove recurrent pterygium firstly and combine amniotic membrane transplantation with excision of recurrent pterygium, especially in Kashgar area of Xinjiang where ocular surface diseases are frequent and corneal transplantation is seriously delayed.

关 键 词：角膜缘干细胞移植 羊膜移植 复发翼状胬肉 

分 类 号：R77[医药卫生—眼科]