保乳术对乳腺癌患者血清标志物、NK细胞、CD19^+细胞及术后复发的影响  

Effect of breast conserving surgery on serum markers,NK cells,CD19^+ cells and postoperative relapse of breast cancer patients

作　　者：孙萍[1] SUN Ping(Department of General Surgery,Oilfield General Hospital in Henan Province,Puyang,Henan,457001)

机构地区：[1]河南省濮阳市油田总医院普外一科,河南濮阳457001

出　　处：《实用临床医药杂志》2018年第15期53-56,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨保乳术对乳腺癌患者血清标志物水平、自然杀伤细胞(NK细胞)、CD19^+细胞水平的影响,分析血清白介素-6(IL-6)水平、NK细胞及CD19^+细胞比例与术后复发的关系。方法选取本院住院且行保乳术治疗的51例Ⅰ~Ⅱ期乳腺癌患者为观察组,另选取同期来院体检的健康女性40例为对照组。检测观察组患者手术前后血清癌胚抗原(CEA)、P-选择素(P-Selectin)、可溶性黏蛋白(SE-cad)、IL-6及白介素-8(IL-8)水平的变化,另检测其全血NK细胞及CD19^+细胞比例的变化,分析血清IL-6水平、NK细胞及CD19^+细胞比例与术后乳腺癌复发的关系。结果观察组所有患者均顺利完成手术,观察组患者术前血清P-Selectin、SE-cad、CAE、IL-6、IL-8水平及NK细胞及CD19^+细胞比例均显著高于对照组(P<0.01);与术前比较,观察组患者术后上述指标均显著降低(P<0.01),且观察组IL-6水平显著高于对照组(P<0.05);与未复发组比较,复发组血清IL-6水平及NK细胞、CD19^+细胞比例均显著升高(P<0.01)。结论保乳术可有效降低乳腺癌患者血清肿瘤标志物水平及相关细胞因子水平,并调节患者NK细胞、CD19^+细胞比例,抑制肿瘤的发生发展。血清IL-6水平及NK细胞、CD19^+细胞比例均可作为预测乳腺癌患者术后复发的有效指标。Objective To explore the effect of breast conserving surgery on the serum markers levels, natural killer cell （NK cell） and CD19 ＋ cell of breast cancer patients, and analyze the relationship between serum interleukin-6 （IL-6） level, NK cell proportion, CD19 ＋ cell proportion and postoperative recurrence. Methods A total of 51 breast cancer patients with Ⅰ～Ⅱ stage were selected as observation group, and another 40 healthy women with physical examination in our hospital were selected as controls. The changes of serum carcino-embryonic antigen （CEA）, P-Selectin（P-Selectin）, soluble epicyte cadherin （SE-cad）, interleukin-6（IL-6） and interleukin-8 （IL-8） levels were detected, the whole blood NK cell and CD19 ＋ cell proportion changes were detected. The relationship between serum interleukin-6 （IL-6） level, NK cell proportion, CD19 ＋ cell proportion and postoperative recurrence were analyzed. Results All patients in observation group were completed the operation, the serum P-Selectin, SE-cad, CAE, IL-6, IL-8 levels and NK cell and CD19 ＋ cell proportion in observation group before operation were higher than that in control group （ P 〈0.01）. Compared with operation before, the above indexes in observation group decreased significantly （ P 〈0.01）, and IL-6 level in observation group was higher than that in control group （ P 〈0.05）, but the other indicator in two groups showed no significant difference （ P 〉0.05）. Compared with no recurrence group, the serum IL-6 level and NK cell and CD19 ＋ cell proportion in recurrence group increased significantly （ P 〈0.01）. Conclusion Breast conserving surgery can reduce serum tumor marker and related cytokines levels, and adjust the NK cell and CD19 ＋ cell proportion of patients,inhibit the occurrence and development of tumor. So the serum IL-6 level, NK cell and CD19 ＋ cell proportion can be an effective indicators in prediction of postoperative recurrence.

关 键 词：保乳术 NK细胞 CD19+细胞 癌胚抗原 P-选择素 可溶性黏蛋白 白介素-6 白介素-8 

分 类 号：R737.9[医药卫生—肿瘤]