缺血性脑卒中患者NT-proBNP和Hcy检测的应用价值研究  

Application value of detection of NT-proBNP and Hcy in patients with ischemic stroke

作　　者：何雪苹 谭娟[2] 刘昀 HE Xue-ping;TAN Juan;LIU Yu(Pangang Group Chengdu Hospital,Panzhihua 617000,China;Affiliated Hospital,North Sichuan Medical College,Nanchong 617000,China)

机构地区：[1]攀钢集团总医院神经内科,四川攀枝花617000 [2]川北医学院附属医院神经内科,四川南充637000

出　　处：《实用医院临床杂志》2018年第4期226-228,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨缺血性脑卒中患者N端脑钠肽前体(NT-proBNP)和血清同型半胱氨酸(Hcy)水平在评估患者预后效果中的应用价值。方法 152例缺血性脑卒中患者(脑卒中组)和同期120例健康志愿者(健康组),检测两组血清NT-proBNP和Hcy水平,同时分析缺血性脑卒中患者脑卒中梗死体积、美国国立卫生研究院卒中量表(NIHSS)评分与NT-proBNP和Hcy表达水平的关系。结果脑卒中组NT-proBNP和Hcy表达水平均高于健康组(P<0.05);不同神经功能损伤程度和脑梗死体积患者,NT-proBNP和Hcy表达水平比较,差异有统计学意义,且轻度损伤(小梗死)<中度损伤(中梗死)<重度损伤(大梗死)(P<0.05);NIHSS评分和脑梗死面积与NT-proBNP、Hcy表达水平呈正相关(P<0.05)。结论缺血性脑卒中患者血清NT-proBNP、Hcy表达水平为高表达,且患者脑梗死面积、NHISS评分与NT-proBNP、Hcy表达水平存在明显相关性,故NTproBNP、Hcy可用于评估缺血性脑卒中病情程度。Objective To investigate the application value of level changes in serum N-terminal probrain natriuretic peptide（ NT-proBNP） and homocysteine（ Hcy） for evaluating the prognosis of patients with ischemic stroke.Methods Serum levels of NTproBNP and Hcy were detected in 152 patients with ischemic stroke（ stroke group） and 120 healthy volunteers（ healthy group）.At the same time,relationship between the stroke infarct size,the U.S.National Institutes of Health Stroke Scale（ NIHSS） score and levels of NT-proBNP and Hcy was analyzed. Results Serum levels of NT-proBNP and Hcy in the stroke group were significantly higher than those in the healthy group（ P〈0. 05）.Levels of NT-proBNP and Hcy were increased significantly with the aggravation of neurological function damage and the increase of cerebral infarct volume,showing that the mild injury（ small infarction） moderate injury（ middle infarction） severe injury（ large infarction）（ all P〈0. 05）.The NIHSS score and the infarct size were positively correlated with the levels of NT-proBNP and Hcy（ P〈0. 05）.Conclusion Serum levels of NT-proBNP and Hcy are high in patients with ischemic stroke.The infarct size and NHISS score are obviously correlated with levels of NT-proBNP and Hcy. Therefore,NT-proBNP and Hcy can be used as sensitive indexes to evaluate the severity of ischemic stroke.

关 键 词：缺血性脑卒中 N端脑钠肽前体 同型半胱氨酸 预后效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]