藜芦醛的合成  

A Study on the Synthesis of Veratraldehyde

作　　者：胡凯 董杰 李想 李冬 赵玉祥 朱颜任 王晶 刘丹丹 周林宗 梁蕾蕾 陈静波[1,2] HU Kai;DONG Jie;LI Xiang;LI Dong;ZHAO Yu-xiang;ZHU Yan-ren;WANG Jing;LIU Dan-dan;ZHOU Lin-zong;LIANG Lei-lei;CHEN Jing-bo(Key Laboratory of Medicinal Chemistry of Natural Resource,Ministry of Education and Yunnan province,Yunnan University,Kunming Yunnan 650091;School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming Yunnan 650500;School of Geographical Science and Tourism Management,Chuxiong Normal University,Chuxiong Yunnan 675000;Basic Medical School of Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]云南大学教育部自然资源药物化学重点实验室,云南昆明650091 [2]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [3]楚雄师范学院地理科学与旅游管理学院,云南楚雄675000 [4]昆明医科大学基础医学院,云南昆明650500

出　　处：《昆明医科大学学报》2018年第6期31-34,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(21662041);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468(-022)];云南省天然药物药理重点实验室开放研究基金资助项目(YZDY1501);云南省教育厅科学研究基金资助项目(2017zzx196)

摘　　要：目的藜芦醛是一类重要的医药中间体和化工原料,在总结其常见合成方法的基础上,进一步研究更加高效的合成路线,为藜芦醛的应用打下良好基础.方法以甲基丁香酚为原料经Triton B催化的烯烃异构化反应和臭氧氧化/还原反应合成藜芦醛.结果探索了反应时间、反应温度、催化剂用量等对实验的影响,筛选出制备藜芦醛的最优化条件,两步反应总产率达到64%.结论此合成路线所用原料易得,反应条件温和,有一定的工业应用价值.Objective Veratraldehyde is an important pharmaceutical intermediate and chemical raw material. Taking common synthetic methods of Veratraldehyde into consideration, the study is aimed to further investigate a more efficient synthetic route in order to provide a solid foundation for the application of Veratraldehyde.Me thods This article introduces an alternative method based on the Triton-B catalyzed olefin isomerization of methyl Eugenol followed by ozonation/reduction reaction.Re s ults In the experiment,the optimal conditions was selected by investigating the influence of reaction time, reaction temperature and catalyst dosage on the yield of Veratraldehyde. The total yield of this 2-step reactions was 64%. Conclus ion The above-mentioned synthesis method only requires raw materials that are easily acquired and its relative reaction conditions are mild, thus it will provide values in the industrial applications.

关 键 词：藜芦醛 合成 烯烃异构化 臭氧氧化/还原 

分 类 号：D919.2[医药卫生—法医学]