急性脑梗死患者sRAGE水平和NIHSS评分、脑白质病变分型、脑血管病危险因素的相关性  

Association of sRAGE Levels with NIHSS Scores, White Matter Lesion Types, and Cerebrovascular Disease Risk Factors in Patients with Acute Cerebral Infarction

作　　者：曹利[1] 戴艳萍[1] 靳美[1] 张春媛[1] 齐丹[1] CAO Li;DAI Yan-ping;JIN Mei;ZHANG Chun-yuan;QI Dan(Department of Neurology,Heilongjiang Provincial Hospital,Harbin,Heilongjiang Province,150001 China)

机构地区：[1]黑龙江省医院神经内科,黑龙江哈尔滨150001

出　　处：《中外医疗》2018年第14期66-68,共3页China & Foreign Medical Treatment

摘　　要：目的探讨急性脑梗死患者sRAGE水平和NIHSS评分、脑白质病变分型、脑血管病危险因素的相关性。方法随机选取2013年5月—2017年5月该院收治的急性脑梗死患者160例,将这些患者作为脑梗死组,另选取同期该院体检健康者160名作为对照组,对两组人员的血浆sRAGE表达水平进行统计分析,并对脑梗死组患者的血浆sRAGE水平影响因素进行单因素分析和多因素Logsitic分析。结果脑梗死组患者的血浆sRAGE表达水平(870.0±100.3)ng/L显著低于对照组(1 032.0±100.5)ng/L(t=4.303,P<0.05)。单因素分析显示,脑梗死组患者的血浆sRAGE水平影响因素包括吸烟、NIHSS评分、DWMH分级、e GFR(P<0.05),血浆sRAGE水平与吸烟、NIHSS评分、DWMH分级、e GFR均呈显著的负相关关系(r=-0.300,-0.372,-0.402,-0.641,P<0.05)。多因素Logsitic分析显示,脑梗死组患者的血浆sRAGE水平影响因素包括吸烟、NIHSS评分、DWMH分级、e GFR(P<0.05)。结论急性脑梗死患者sRAGE水平和NIHSS评分、脑白质病变分型、脑血管病危险因素均显著相关。Objective This paper tries to explore the correlation between sRAGE levels and NIHSS scores, white matter lesion type, and cerebrovascular disease risk factors in patients with acute cerebral infarction. Methods A total of 160 patients with acute cerebral infarction treated in our hospital from May 2013 to May 2017 were selected randomly. These patients were treated as cerebral infarction group, and 160 patients who were healthy in our hospital during the same period were selected as control group. The sRAGE expression level was statistically analyzed, and the influencing factors of plasma sRAGE levels in cerebral infarction patients were analyzed by univariate analysis and multivariate Logistic analysis. Results The plasma sRAGE expression level in patients with cerebral infarction was（870.0 ±100.3） ng/L, which was significantly lower than that of the control group（1 032.0±100.5） ng/L（t=4.303, P〈0.05）. Univariate analysis showed that plasma sRAGE levels in patients with cerebral infarction were affected by smoking, NIHSS scores, DWMH grading, and e GFR（P〈0.05）.Plasma sRAGE levels were negatively correlated with smoking, NIHSS scores, DWMH grading, and e GFR（r=-0.300,-0.372,-0.402,-0.641, P〈0.05）. Multivariate logistic analysis showed that plasma sRAGE levels in patients with cerebral infarction included smoking, NIHSS scores, DWMH grading, and e GFR（P〈0.05）. Conclusion Patients with acute cerebral infarction were significantly associated with sRAGE levels and NIHSS scores, white matter lesions, and cerebrovascular disease risk factors.

关 键 词：急性脑梗死 sRAGE水平 NIHSS评分 脑白质病变分型 脑血管病危险因素 

分 类 号：R74[医药卫生—神经病学与精神病学]