凝血因素在肝纤维化发生发展中的作用  

Research advances in the role of coagulation factors in liver fibrosis

作　　者：李素新[1] 李路豪 党晓卫[1] LI Suxin;LI Luhao;DANG Xiaowei(Department of Hepatopancreatobiliary Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院肝胆胰外科,郑州450052

出　　处：《临床肝胆病杂志》2018年第7期1547-1550,共4页Journal of Clinical Hepatology

基　　金：河南省科技厅科技攻关项目(132102310424)

摘　　要：目前包括肝脏在内的器官纤维化的研究发现,凝血因素和炎症反应共同促进了脏器纤维化的进展,使人们认识到凝血因素的变化不仅仅是肝纤维化的继发性事件,其在肝纤维化的发生发展中,起到了重要的参与作用。总结近年的相关研究发现具有血栓倾向的因子多促进肝纤维化,而具有出血或溶血倾向的因子多抑制肝纤维化。应用抗凝治疗,能明显改善纤维化进展情况。因此应用抗凝治疗或许能为未来肝纤维化提供治疗方向。综述了目前国内外关于凝血因素在肝纤维化中的作用。Present studies on organ fibrosis including liver fibrosis show that coagulation factors and inflammatory response promote the progression of organ fibrosis,which makes people to be aware of the fact that the change in coagulation factors is not only a secondary event to liver fibrosis,and coagulation factors also play an important role in the development and progression of liver fibrosis. Recent studies have shown that most of the coagulation factors with thrombotic tendency promote liver fibrosis,while those with bleeding or hemolytic tendency inhibit liver fibrosis. Anticoagulant therapy can significantly improve or alleviate liver fibrosis,and therefore,it may provide a direction for the treatment of liver fibrosis in future. This article reviews the research advances in the role of coagulation factors in liver fibrosis.

关 键 词：肝硬化 凝血因素 炎症 综述 

分 类 号：R575.2[医药卫生—消化系统]