基于主成分分析方法的“孙络—微血管”病变数学模型构建及通络干预研究  

PCA based mathematic model construction and collateral dredging intervention of "tertiary collaterals microvessel" lesions

作　　者：常丽萍 李禄金 魏聪 贾振华[4] 郑青山 吴以岭 CHANG Liping , LI Lujin, WEI Cong, JIA Zhenhua, ZHENG Qingshan, WU Yiling.(Hebei Yiling Pharmaceutical Research Institute, National Key Laboratory （Collateral Disease of Cardiac and Cerebral Vessels） of SATCM, Shijiazhuang 050035,China)

机构地区：[1]河北以岭医药研究院/国家中医药管理局国家重点研究室(心脑血管络病),石家庄050035 [2]上海中医药大学药物临床研究中心,201203 [3]络病研究与创新中药国家重点实验室,石家庄050035 [4]河北以岭医院/国家中医药管理局中医络病学重点学科,石家庄050091

出　　处：《疑难病杂志》2018年第7期649-653,666,共6页Chinese Journal of Difficult and Complicated Cases

基　　金：国家重点基础研究发展计划(973计划)资助项目(2012CB518606);国家重点研发计划资助项目(2017YFC1700501);河北省科技计划(国际科技合作专项)资助项目(16397784D);河北省人才培养工程资助项目(A201500539)

摘　　要：目的探讨微血管内皮细胞(EC)在"孙络—微血管"病变急性心肌梗死、心肌梗死后心律失常、心肌梗死后心力衰竭、缺血性脑卒中、糖尿病肾病等重大疾病中的效应规律和关键作用靶点,并构建数学模型。方法利用主成分分析方法对国家973计划项目"基于心脑血管病变的脉络学说理论研究"各子课题单位中"孙络—微血管"病变相关研究数据,构建数学模型进行数学分析。结果"孙络—微血管"病变涉及到微血管(微循环)、血液成分、神经体液、脏器组织等4类指标群存在显著相关性;通络干预微血管(微循环)优势明显;心脑(糖)肾重大疾病均是以微血管内皮细胞为核心,共同组成了复杂的相互作用关系网络,通络药物干预使其趋于正常,其中一氧化氮(NO)、内皮素-1(ET-1)等多个指标是关键共性靶点。结论"孙络—微血管"病变是以微血管内皮细胞为核心和启动因素、神经体液和血液成分共同参与、组织细胞功能结构损伤、多维时空动态演变的复杂网络病变规律,通络干预使该复杂网络中相互关联的节点趋于正常,提示心脑(糖)肾可异病同治。Objective To investigate mechanism and key effect targets of these cells in major ＂ tertiary collaterals microvessel＂ lesions, including acute myocardial infarction, post MI arrhythmia,post MI heart failure, cerebral ischemic stroke and diabetic nephropathy. Methods Principal component analysis（PCA） was used to construct mathematical model and conduct mathematical analysis for ＂ tertiary collaterals microvessel＂ lesions related research data from each sub topic of ＂ meridian doctrine theory research based on cardiocerebral vascular diseases＂ of the National 973 Program. Results ＂ Tertiary collaterals microvessel＂ lesion involves four types of indicator groups： microvessels（micro circulation）, blood component, neurohumour and visceral organ,which were significantly correlated. Collateral dredging intervention of microvessel（micro circulation） has obvious advantage. Major diseases including heart,brain（diabetes） and kidney diseases, all use microvascular endothelial cells as the core,and jointly constitute complex network of interaction. Collateral dredging intervention can make them tend to be normal. Indicators such as NO and ET-1 are the key targets of generality. Conclusion ＂ Tertiary collaterals microvessel＂ lesion is a complex network lesion with micro vascular EC as the core, involving neurohumour and blood components, as well as featured by structural and functional damages of tissue, cell and multi-dimensional spatiotemporal dynamics evolution. Collateral dredging intervention can make inter-correlated nodes in this complex network tend to be normal, suggesting that heart, brain（diabetes） and kidney diseases can be subject to homotherapy for heteropathy.

关 键 词：“孙络—微血管”病变 数学模型构建 多维时空动态演变 复杂网络 微血管内皮细胞 异病同治 

分 类 号：O157.5[理学—数学] R363[理学—基础数学]