三氧化二砷辅助治疗肝癌癌性疼痛的临床观察  

Clinical observation of arsenic trioxide in the adjuvant treatment of cancerous pain in liver cancer

作　　者：王新亭[1] 张传雷[1] 陈晓琦[1] 冀爱英[1] 袁媛[1] 陈欣菊[1] WANG Xinting;ZHENG Chuanlei;CHEN Xiaoqi;Jl Aiying;YUAN Yuan;CHEN Xinju(Department of Gastroenterology,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院消化内科,郑州450000

出　　处：《右江医学》2018年第3期314-317,共4页Chinese Youjiang Medical Journal

摘　　要：目的观察三氧化二砷辅助治疗肝癌癌性疼痛的临床疗效。方法将40例肝癌癌性疼痛患者随机分为观察组和对照组,每组20例,对照组给予吗啡缓释片口服治疗,观察组给予吗啡缓释片口服的同时给予三氧化二砷规律输注,14天为一疗程。观察两组患者VAS评分、吗啡缓释片用量、疼痛缓解持续时间、爆发痛次数及生存质量改善率。结果观察组治疗14天后的VAS评分低于对照组,吗啡用量少于对照组,疼痛缓解持续时间较对照组长,爆发痛次数较对照组少,比较差异均有统计学意义(P<0.05或0.01)。观察组生存质量改善率为65%(13/20),对照组生存质量改善率为30%(6/20),两组比较差异有统计学意义(χ~2=4.912,P=0.027),观察组生存质量改善率更高。三氧化二砷治疗不良反应率为20%(4/20),经对症治疗后好转,不影响持续治疗。结论三氧化二砷联合吗啡缓释片能够有效缓解肝癌癌性疼痛,且缓解持续时间长,同时可以减少吗啡的用量及爆发痛的次数,改善患者的生存质量。Objective To observe the clinical efficacy of arsenic trioxide in the adjuvant treatment of liver cancer.Methods 40 liver cancer patients with cancerous pain were randomly divided into observation group and control group,with 20 cases in each group. The control group were given morphine sustained release tablets orally. The observation group were given morphine sustained release tablets while regularly injecting arsenic trioxide,with 14 days as a course of treatment. VAS score,the dosage of morphine sustained release tablets,the duration of pain relief,the outbreaks of cancerous pain and the improvement rate of the quality of life were observed between the two groups. Results After 14 days of treatment,the VAS score of the observation group was lower than that of the control group,the dosage of morphine was less,the duration of pain relief was longer and the outbreaks of cancerous pain were less than those of the control group,difference was statistically significant（ P〈0.05 or 0.01）. The improvement rate of quality of life was 65%（ 13/20） in the observation group and 30%（ 6/20） in the control group,difference was statistically significant（ χ^2= 4.912,P = 0.027）,the improvement rate of quality of life was higher in the observation group. The adverse reaction rate of arsenic trioxide treatment was 20%（ 4/20）,which improved after symptomatic treatment,and did not affect continuous treatment. Conclusion Arsenic trioxide combined with morphine sustained release tablets can effectively relieve the pain of liver cancer for a long time. At the same time,it can reduce the dosage of morphine and the outbreaks of cancerous pain,and improve the quality of life of patients.

关 键 词：原发性肝癌 癌性疼痛 三氧化二砷 

分 类 号：R735.7[医药卫生—肿瘤]