双歧杆菌与复方谷氨酰胺肠溶胶囊联合用药对胃肠功能紊乱患者肠粘膜屏障功能以及炎症因子的影响  

Effects of bifidobacterium combined with compound glutamine enteric-coated capsules on intestinal mucosal barrier and inflammatory cytokines in patients with gastrointestinal disorders

作　　者：郑丽萍[1] 文武[1] Zheng Li ping;Wen Wu(Gastroenterology of the Second People＇s Hospital of Chengdu,Sichuan Chengdu 610017)

机构地区：[1]成都市第二人民医院消化内科,四川成都610017

出　　处：《四川生理科学杂志》2018年第2期102-105,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨双歧杆菌与复方谷氨酰胺肠溶胶囊联合用药对胃肠功能紊乱患者肠粘膜屏障功能以及炎症因子的影响。方法:选取2016年4月至2017年10月在我院进行治疗的胃肠功能紊乱腹泻患者100例进行研究。采用随机数字表法将患者分为对照组和观察组,每组各50例。两组患者均进行补液、纠正电解质平衡等常规治疗,对照组在常规治疗基础上给予双歧杆菌活菌胶囊,每次2粒,早晚各1次,观察组在对照组基础上加以复方谷氨酰胺肠溶胶囊饭前口服,一日3次,一次2-4粒,两组疗程均为8w。观察两组患者疗效(以临床症状、大便次数、常规检查为疗效评价指标)、肠粘膜屏障功能指标(血浆二胺氧化酶、降钙素原及尿乳果糖/甘露醇比值)和炎症因子指标(超敏C反应蛋白、肿瘤坏死因子α、白介素6)。治疗前及疗程结束后采用酶联免疫吸附试验检测血浆二胺氧化酶、降钙素原、C反应蛋白、肿瘤坏死因子α、白介素6,高效液相色谱-示差法测定尿乳果糖/甘露醇比值。结果:观察组有效率为96.9%,明显高于对照组的82.0%(P<0.05)。治疗后两组血浆二胺氧化酶、降钙素原及尿乳果糖/甘露醇比值均明显下降(P<0.05),但观察组下降幅度明显大于对照组(P<0.05)。两组治疗后超敏C反应蛋白、肿瘤坏死因子α、白介素6均明显下降(P<0.05),但观察组下降幅度更为明显(P<0.05)。结论:双歧杆菌与复方谷氨酰胺肠溶胶囊联合用药治疗胃肠功能紊乱较单独使用双歧杆菌可明显提高疗效,提高肠道粘膜屏障功能,降低炎症反应。Objective：To investigate the effects of the combination of bifidobacterium and compound glutamine enteric-coated capsules on intestinal mucosal barrier function and inflammatory cytokines in patients with gastrointestinal disorders.Methods：A total of 100 patients with gastrointestinal dysfunction diarrhea admitted to our hospital from April 2016 to October 2017 were randomly divided into the control group and the observation group with 50 cases in each group.The two groups received routine treatments such as rehydration,correction of electrolyte balance,etc.The control group was given Bifidobacterium viable Capsule on the basis of conventional treatment.The observation group was given oral administration of compound Glutamin Entersoluble capsules.To observe the efficacy of the two groups（with clinical symptoms,stool frequency,routine examination for the efficacy evaluation）,intestinal mucosal barrier function（two plasma monoamine oxidase,procalcitonin and lactulose/mannitol ratio）and inflammation index（high sensitivity C reactive protein,tumor necrosis factor alpha,interleukin 6）were measured.Plasma two amine oxidase,procalcitonin,C reactive protein,tumor necrosis factor alpha,and interleukin 6 were detected by enzyme-linked immunosorbent assay before and after treatment.The lactulose/mannitol ratio was determined by high performance liquid chromatography.Results：The effective rate of the observation group was 96.9%,which was significantly higher than that of the control group（82%,P〈0.05）.After treatment,the ratio of two amine oxidase,procalcitonin and lactulose/mannitol in the two groups decreased significantly（P〈0.05）.And the decreases in the observation group was significantly larger than that in the control group（P〈0.05）.After treatment,hypersensitivity C reactive protein,tumor necrosis factor alpha,and interleukin 6 were significantly decreased in the two groups（P〈0.05）.But the decreases in the observation group was higher（P〈0.05）.Conclusion：Bifidobacterium c

关 键 词：双歧杆菌 复方谷氨酰胺肠溶胶囊 胃肠功能为乱 肠粘膜屏障功能 炎症因子 

分 类 号：R57[医药卫生—消化系统]