TTF-1在非小细胞肺癌中的表达及意义  

Expression and significance of TTF-1 in non-small cell lung cancer

作　　者：杨莹[1] 梁新梅[1] 卢翠梅[1] 陆薇[1] 梁克诚 YANG Ying;LIANG Xin-mei;LU Cui-mei;LU Wei;LIANG Ke-cheng(Department of Respiratory Medicine,the First Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou,Guangxi 545002,China)

机构地区：[1]广西科技大学第一附属医院呼吸内科,广西柳州545002 [2]广西科技大学第二附属医院呼吸内科,广西柳州545006

出　　处：《临床肺科杂志》2018年第8期1491-1493,1497,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨甲状腺转录因子-1(TTF-1)在非小细胞肺癌(NSCLC)中的表达及意义。方法选取2014年1月至2015年8月NSCLC组织标本114例,同时选取癌旁正常组织(距肿瘤边缘≥5cm)和114例炎症组织作为对照,采用免疫组化染色法检测TTF-1表达。结果NSCLC组织TTF-1阳性表达率为42.11%,明显高于癌旁组织和炎症组织(p<0.05);腺癌、Ⅱ期和有淋巴结转移患者TTF-1阳性表达分别为57.63%、60.47%和68.75%,明显高于其他病理类型、Ⅰ期和无淋巴结转移患者(p<0.05);高分化患者TTF-1阳性表达为22.86%,明显低于中低分化患者(p<0.05);TTF-1阴性表达患者中位无进展生存时间(PFS)为18.71个月,明显短于TTF-1阳性表达患者的27.67个月(p<0.05);TTF-1阴性表达患者中位总生存期(OS)为21.31个月,明显短于TTF-1阳性表达患者的30.00个月(p<0.05)。结论 TTF-1表达与NSCLC患者临床病理特征及预后有一定关系,值得进一步研究。Objective To investigate the expression and significance of thyroid transcription factor-1（ TTF-1） in non-small cell lung cancer（ NSCLC）. Methods 114 cases of NSCLC tissue preserved in pathology department from January 2014 to August 2015 were selected as the study group,and the adjacent normal tissue（ from the tumor edge ≥5 cm） and 114 cases of inflammatory tissue were selected as the control group. Immunohistochemical staining was used to detect the expression of TTF-1. Results The positive rate of TTF-1 expression in NSCLC tissues was 42. 11%,which was higher than that in adjacent tissues and inflammatory tissue（ P〈0. 05）. The positive expression of TTF-1 in adenocarcinoma,stage II and lymph node metastasis were 57. 63%,60. 47% and 68. 75%,which were all significantly higher than those of other pathological types,stage I,and without lymph node metastasis（ P〈0. 05）. The positive expression of TTF-1 in high differentiated patients was 22. 86%,which was significantly lower than that in patients with middle or low differentiation（ P〈0. 05）. The median progression free period（ PFS） of patients with TTF-1 positive expression was 18. 71 months,significantly shorter than TTF-1 negative patients with 27. 67 months（ P〈0. 05）. The median overall survival time（ OS） of patients with TTF-1 positive expression was 21. 31 months,significantly shorter than TTF-1 negative patients with 30 months（ P〈0. 05）. Conclusion The expression of TTF-1 is related with the clinicopathological features and prognosis of NSCLC patients,and deserves further study.

关 键 词：甲状腺转录因子-1 非小细胞肺癌 临床病理 预后 

分 类 号：R734.2[医药卫生—肿瘤]