多奈哌齐合胞磷胆碱治疗血管性认知障碍的临床观察  

Clinical observation of donepezil combined with citicoline in the treatment of vascular cognitive impairment

作　　者：汲晶[1] 何琳琳[1] 龙海泳 杜文华[1] Ji Jing;He Linlin;Long Haiyong;Du Wenhua(The Integrated Traditional Chinese Medicine and Western Medicine Hospital of Changping District in Beijing City 102208)

机构地区：[1]北京市昌平区中西医结合医院,102208

出　　处：《中国社区医师》2018年第19期23-24,共2页Chinese Community Doctors

摘　　要：目的:探讨多奈哌齐联合胞磷胆碱治疗血管性认知障碍(VCI)的临床效果。方法:收治血管性认知障碍患者102例,随机分为两组,每组51例。A组给予多奈哌齐治疗,B组给予多奈哌齐联合胞磷胆碱钠片治疗,比较两组临床疗效及治疗前后日常生活能力量表(ADL)评分、蒙特利尔认知评估量表(MoCA)评分、简明智力状态检查量表(MMSE)评分。结果:治疗后B组总有效率明显高于A组,差异有统计学意义(P<0.05)。治疗后B组MoCA、MMSE以及ADL评分明显优于A组,差异有统计学意义(P<0.05)。结论:多奈哌齐联合胞磷胆碱治疗血管性认知障碍(VCI)的临床效果显著,可改善患者的认知功能。Objective：To investigate the clinical effect of donepezil combined with citicoline in the treatment of vascular cognitive impairment（VCI）.Methods：102 cases of patients with vascular cognitive impairment were divided into two groups randomly,with51 cases in each group.Group A was treated with donepezil,and group B was treated with donepezil combined with citicoline sodium tablets,the clinical effect,activity of daily living scale（ADL） score,montreal cognitive assessment scale（MoCA） score and mini mental status examination（MMSE） score between the two groups were compared.Results：After treatment,the total effective rate of group B was significantly higher than that of group A,and the difference was statistically significant（P〈0.05）.After treatment,the scores of MoCA,MMSE and ADL in group B were significantly better than those in group A,and the difference was statistically significant（P〈0.05）.Conclusion：Donepezil combined with citicoline was effective in the treatment of vascular cognitive impairment（VCI）,which could improve the cognitive function of patients.

关 键 词：胞磷胆碱钠片 多奈哌齐 血管性认知障碍 

分 类 号：R749.13[医药卫生—神经病学与精神病学]