糖尿病早期视网膜神经元退行性病变与自噬的相关性研究现状  

Current situation of research on the relationship between early diabetic retinal neuronal degeneration and autophagy

作　　者：李贵富 李春霞 LI Guifu, LI Chunxia.(Shanghai TCM-integrated Hospital,Shanghai University of TCM, Shanghai 200082, China)

机构地区：[1]上海中医药大学附属上海市中西医结合医院眼科,上海200082

出　　处：《中国中医眼科杂志》2018年第2期123-126,共4页China Journal of Chinese Ophthalmology

基　　金：上海市卫生和计划生育委员会科研课题(20164025)

摘　　要：糖尿病视网膜病变(DR)是一种微血管系统疾病,越来越多的研究表明糖尿病视网膜神经元退行性病变是DR的早期表现特征。糖尿病导致的异常代谢改变是发生视网膜神经元退行性病变的主要病理因素,其过程与DR的发展互相关联。自噬是维持细胞内环境稳态和细胞存活的重要代谢途径之一,自噬在糖尿病视网膜神经元退行性病变的相关改变中发挥重要作用。研究二者之间的联系可能为DR的预防和治疗提供新的策略。Diabetic retinopathy（DR） is a microvascular system disease. More and more studies have shown that diabetic retinal neuronal degeneration is the early manifestation of DR.The abnormal metabolic changes caused by diabetes mellitus are the main pathological factors for the retinal neuronal degeneration, and its process is related to the development of DR. Autophagy is one of the important metabolic pathways maintaining the cell homeostasis and viability. Au-tophagy plays an important role in the related changes of diabetic retinal neuronal degeneration.Exploration on relationship between autophagy and diabetic retinal neuronal degeneration may provide a new strategy for the prevention and treatment of DR.

关 键 词：糖尿病视网膜病变 视网膜神经元退行性病变 视网膜神经节细胞 视网膜MÜLLER细胞 自噬 

分 类 号：R774.1[医药卫生—眼科]