Early candidate biomarkers found from urine of glioblastoma multiforme rat before changes in MRI  

作　　者：Yanying Ni Fanshuang Zhang Manxia An Wei Yin Youhe Gao 

机构地区：[1]Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College [2]Department of Pathology, Aviation General Hospital of China Medical University [3]Department of Biochemistry and Molecular Biology, Beijing Normal University, Gene Engineering Drug and Biotechnology Beijing Key Laboratory

出　　处：《Science China(Life Sciences)》2018年第8期982-987,共6页中国科学（生命科学英文版）

摘　　要：Dear Editor, Gliomas are the most frequent primary tumors of the central nervous system, accounting for more than 60% of all brain tumors （Wang and Bettegowda, 2015）. Among them, glio-blastoma multiforme （GBM） is the most common aggressive glioma, and the average survival rate remains low （Chen et al., 2015）. The standard combination of surgery and radio-therapy or chemotherapy can only extend the progression-free survival time for 12-18 months, with a high risk of re-currence （Li et al., 2008）. In addition, the incidence of GBM has increased annually by 1%-2% in the past years （Louis et al., 2007）. Therefore, a precise early diagnosis of GBM is crucial for the early determination of appropriate therapeutic strategies.Dear Editor,Gliomas are the most frequent primary tumors of the central nervous system,accounting for more than 60%of all brain tumors(Wang and Bettegowda,2015).Among them,glioblastoma multiforme(GBM)is the most common aggressive glioma,and the average survival rate remains low(Chen et al.,2015).The standard combination of surgery and radiotherapy or chemotherapy can only extend the progressionfree survival time for 12–18 months,with a high risk of recurrence(Li et al.,2008).In addition,the incidence of

关 键 词：候选人 MRI 老鼠 神经系统 放射疗法 脑肿瘤 尿 治疗学 

分 类 号：R739.4[医药卫生—肿瘤]