动脉灌注化疗联合放射治疗中晚期食道癌血清标记物及生存率的影响  

Influence of arterial perfusion chemotherapy combined radiotherapy on advanced esophageal carcinoma,serum marker and survival rate

作　　者：樊高飞[1] 刘亚贝[1] 黄金[1] 翁呈韬[1] 张腾跃[1] 段巧虹[1] FAN Gao-fei;LIU Ya-bei;HUANG Jin;WENG Cheng-tao;ZHANG Peng-yue;DUAN Qiao-hong(Department of Oncology,Anhui Tumor Hospital,Hefei 230031,China)

机构地区：[1]安徽省肿瘤医院肿瘤内二科,安徽合肥230031

出　　处：《中国中西医结合消化杂志》2018年第7期557-560,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]研究动脉灌注化疗联合放射治疗中晚期食管癌的临床疗效及对患者血清肿瘤标记物及生存率的影响。[方法]选择来我院住院治疗的82例中晚期食管癌患者并将其随机分为观察组42例和对照组40例,2组均给予放射治疗,观察组在此基础上给予介入化疗,观察和比较2组的临床治疗效果,治疗前后血清癌抗原125(cancer antigen 125,CA125)、癌胚抗原(carcinoembryonic antigen,CEA)、人糖连抗原199(Carbohydrate antigen199,CAl9-9)和鳞状细胞癌相关抗原(squamous cell carcinoma antigen,SCC)水平的变化及1、2、3年的生存率情况。[结果]治疗后,观察组完全缓解率和总缓解率均明显高于对照组(P<0.05)。观察组治疗后1、2和3个月的血清CEA、CA125、CA199和SCC水平均显著低于对照组(P<0.05),生存率明显高于对照组(58.62%34.78%,41.37%26.08%,20.69%17.39%,χ~2=2.9199,1.3253,0.0898,P>0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。[结论]动脉灌注化疗联合放射治疗中晚期食道癌的临床疗效明显优于单纯放射治疗,能有效的改善患者的血清肿瘤标记物水平,提高患者的生存率,并且不会明显增加患者的不良反应。[Objective]To investigate clinical efficiency of combined intervention chemotherapy and radiotherapy in treating advanced esophageal carcinoma,and its influence on serum tumor marker as well as survival rate.[Methods]A total of 82 cases with advanced esophageal carcinoma admitted in our hospital were selected and divided into observation group（42 cases）and control group（40 cases）.Both of the groups received radiotherapy,while the observation group received intervention chemotherapy on that basis.The clinical effects of two groups were observed and compared;including change of serum CEA,CA125,CA199 and SCC levels,and survival rates of two groups 1,2 and 3 years after treatment.[Results]After treatment,the complete and total emission rates in observation group were all higher than that in control group（P0.05）;the serum CEA,CA125,CA199 and SCC levels in observation group 1,2 and 3 months after treatment respectively were 56.75%,48.65%,35.13%,which were significantly higher than that of control group（P0.05）;the survival rates in observation group（56.75%,48.65%and 35.13%）were significantly higher than that of control group（58.62% vs.34.78%,41.37% vs.26.08%,20.69% vs.17.39%χ2=2.9199,1.3253,0.0898,P0.05）.The comparative difference between two groups in adverse reaction was not statistically significant（P0.05）.[Conclusion]The application of intervention chemotherapy to advanced esophageal carcinoma can improve clinical effect and enhance level of serum tumor marker;it contributes to increase patients＇ survival rate.

关 键 词：食管癌 介入化疗 血清肿瘤标记物 生存率 

分 类 号：R735.1[医药卫生—肿瘤]