痴呆预防的最新研究进展  

Recent research advances in the prevention of dementia

作　　者：李玉旺[1] LI Yu-wang(Department of Neurology,Tianjin Huanhu Hospital,Tianjin 300060,China)

机构地区：[1]天津市环湖医院神经内科,天津300060

出　　处：《中国城乡企业卫生》2018年第8期43-45,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：痴呆是一种常见的、使人衰弱的综合征,对个人和社会产生巨大的影响。预防疾病的发生或进展将对公共卫生和社会效益产生重大作用。在这篇综述中,作者讨论了痴呆相关干预措施的最新证据,这些证据显示了预防认知能力下降的前景。作者对现有的证据进行了评估,主要是从随机对照试验、系统回顾和荟萃分析中得出的,但也涉及了人类的观察性研究和在模型中的相关工作。总的来说,目前有证据表明,任何预防策略与痴呆的发展或进展之间存在着因果关系。然而,迄今为止的研究表明,多因素干预可能对预防认知下降最有希望,这包括定期锻炼和健康饮食,以及血管风险因素的改善、社会心理压力和重度抑郁发作。作者将讨论这一研究领域的挑战、未来方向和影响。Dementia is a common,debilitating syndrome that has a huge impact on individuals and soci eties.Prevention of onset or progress will have a major impact on public health and social benefits.In this review,we discuss the latest evidences of dementia interventions that show the promise of preventing cognitive decline.We evaluated the existing evidence,mainly from randomized controlled trials,systematic review and meta-analysis of concluded,but also involves the human observational studies and related work in the model.Overall,the evidences showed that there is a cause-and-effect relationship between any prevention strategy and the development or progression of dementia.So far,however,research has shown that mul tifactorial intervention may be the most promising way to prevent cognitive decline,which includes regular exercise and healthy eating,as well as the improvement of vascular risk factors,the social psychological pressure and severe depressive episode.We will discuss the challenges,future directions and influence of this research area.

关 键 词：认知下降 痴呆 地中海饮食 轻度认知功能损害 

分 类 号：R742.1[医药卫生—神经病学与精神病学]