帕金森病认知功能障碍与血糖和脑白质损伤的相关性  

Correlation of cognitive dysfunction of Parkinson's disease with blood glucose and leukodystrophy

作　　者：胡珍琼[1] 江健 曾非[2] 张荣[1] 丁轶[1] HU Zhenqiongl;JIANG Jian;ZENG Fei;ZHANG Rong;DING Yi(Department of Neurology,Hubei Aerospace Hospital,Xiaogan Hubei 432000;Department of Neurology,Renmin Hospital of Wuhan University,Wuhan 430070,China)

机构地区：[1]湖北航天医院神经内科,湖北孝感432000 [2]武汉大学人民医院神经内科,武汉430070

出　　处：《临床与病理杂志》2018年第7期1499-1503,共5页Journal of Clinical and Pathological Research

基　　金：中国航天科工集团医疗卫生科研项目医疗类(2015-LCYL-012)~~

摘　　要：目的:探讨帕金森病(Parkinson’s disease,PD)认知功能障碍与血糖以及脑白质损伤的相关性。方法:选择湖北航天医院和武汉大学人民医院2015年6月至2017年12月收治的86例PD患者作为观察组,并选取同期来院检查的80例健康人作为对照组,比较两组的认知功能、脑白质损伤以及血糖水平,分析PD患者认知功能障碍与血糖以及脑白质损伤的相关性。结果:PD患者的简易智能状态监测(Mini-Mental Sate Examination,MMSE)量表和蒙特利尔认知(Montreal Cognitive Assessment,Mo CA)量表评分与糖化血红蛋白(Hb A1c)、空腹血糖(fasting plasma glucose,FPG)水平、胆碱能通路病变评分量表(Cholinergic Pathways Hyperintensities Scale,CHIPS)评分以及侧脑室前角、侧脑室旁、额叶评分呈负相关(P<0.05),与餐后2 h血糖(postprandial plasma glucose,PPG)水平无相关性(P>0.05)。结论:PD认知功能障碍评分与Hb A1c,FPG水平以及脑白质损伤程度呈负相关。Objective： To investigate the correlation of cognitive impairment in Parkinson＇s disease with blood glucose and white matter damage. Methods： A total of 86 patients with Parkinson＇s disease who were admitted to our hospital from June 2015 to December 2017 were selected as the observation group, and 80 healthy people who were examined at the same hospital for the same period were selected as the control group, the cognitive function, white matter damage, and blood glucose levels were compared between the two groups, and the correlation between cognitive dysfunction and blood glucose and white matter damage was analyzed in Parkinson＇s disease patients. Results： The Mini-Mental Sate Examination（MMSE） and Montreal Cognitive Assessment（Mo CA） scores of patients with Parkinson＇s disease were negatively correlated with Hb A1 c, fasting plasma glucose（FPG） levels, the Cholinergic Pathways Hyperintensities Scale（CHIPS） scores, anterolateral occipital horn, lateral ventricle, frontal lobe scores（P〈0.05）, and had no correlation with 2 h postprandial plasma glucose（PPG） levels（P〉0.05）. Conclusion： The cognitive impairment scores of Parkinson＇s diseases are negatively correlated with Hb A1 c, FPG blood glucose level and the degree of white matter damage.

关 键 词：帕金森病 认知功能障碍 血糖 脑白质损伤 

分 类 号：R742.5[医药卫生—神经病学与精神病学]