CT或彩色多普勒超声引导下经皮穿刺微波消融术治疗肝癌的疗效及对患者血清学指标和免疫功能的影响  

Effects of percutaneous microwave ablation under the guidance of CT or color Doppler ultrasound in the treatment of liver cancer and its influence on serological indexes and immune function

作　　者：张贤兵[1] 李福华 彭秀兰 刘雯[1] ZHANG Xian-bing;LI Fu-hua;PENG Xiu-lan;LIU Wen(the First Department of Hepatology,NO.2 People＇s Hospital of Fuyang City,Anhui,Fuyang 236015,China;Department of Hepatology,Fifth Hospital in Wuhan,Wuhan 430050,China)

机构地区：[1]阜阳市第二人民医院肝病一科,安徽阜阳236015 [2]武汉市第五医院肝病科,武汉430050

出　　处：《中国医学前沿杂志（电子版）》2018年第7期76-79,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：湖北省卫生计生委青年人才项目(WJ2017Q034)

摘　　要：目的探讨CT或彩色多普勒超声引导下经皮穿刺微波消融术治疗肝癌的疗效及对患者血清学指标和免疫功能的影响。方法选取2017年2月至2017年10月就诊于阜阳市第二人民医院肝病科并确诊为原发性肝癌患者103例为研究对象,采用随机数表法将患者分为观察组(73例)和对照组(30例)。观察组患者采用CT或彩色多普勒超声引导下经皮穿刺微波消融术治疗,对照组患者采用经肝动脉化疗栓塞(transarterial arterial chemoembolization,TACE)治疗,对比两组患者的临床疗效、术前和术后6个月糖类抗原(carbohydrate antigen,CA)125、CA199、癌胚抗原(carcino-embryonic antigen,CEA),甲胎蛋白(alpha fetal protein,AFP)及免疫球蛋白(immunoglobulin,Ig)G、IgA、IgM水平变化情况。结果观察组患者治疗总有效率显著高于对照组(P<0.05);术后6个月,观察组患者CA125、CA199、CEA、AFP、IgG、IgM水平均显著低于对照组(P_均<0.05);两组患者IgA水平对比差异无显著性(P>0.05)。结论 CT或彩色多普勒超声引导下经皮穿刺微波消融术,可提高肝癌治疗效果,降低肿瘤标志物水平,改善机体免疫功能。Objective To investigate the effects of percutaneous microwave ablation under the guidance of CT or color Doppler ultrasound in the treatment of liver cancer, the changes of serological indexes and the effects on the immune function of the patients. Method From February 2017 to October 2017, 103 patients with primary liver cancer in NO.2 People＇s Hospital of Fuyang City were selected, they were divided into observation group（n = 73） and control group（n = 30） by random number table method. Observation group patients were treated with percutaneous microwave ablation guided by CT or color Doppler ultrasound, and control group patients were treated with transcatheter arterial chemoembolization（TACE）. The clinical efficacy, and the levels of carbohydrate antigen（CA） 125, CA199, carcino-embryonic antigen（CEA）, alpha fetal protein（AFP）, immunoglobulin（Ig） G, IgA, IgM before and 6 months after operation were compared between the two groups. Result The total effective rate of observation group was significantly higher than that of control group（P〈0.05）. 6 months after operation, the levels of CA125, CA199, CEA, AFP, IgG and Ig M were significantly lower than those of control group（Pall〈0.05）. There was no significant difference in the level of Ig A between the two groups（P〈0.05）. Conclusion Percutaneous microwave ablation guided by CT or color Doppler ultrasound can improve the therapeutic effect of liver cancer, reduce the levels of tumor markers and improve the immune function of the body.

关 键 词：经皮穿刺 微波消融 肝癌 血清学指标 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]