How Spines Cross-Talk： Compartmental Model of Heterosynaptic Plasticity  

作　　者：Zhang Zhong Li Yinyun 

机构地区：[1]School of Government Management, Beijing Normal University, Beijing 100875, China [2]School of Systems Science, Beijing Normal University, Beijing 100875, China [3]III Institute of Physics-Biophysics, Georg-August University Goettingen, Goettingen 37077, Germany

出　　处：《Journal of Pharmacy and Pharmacology》2018年第8期712-728,共17页药剂与药理学（英文版）

基　　金：We would like to thank Prof. Florentin Woergoetter, Dr. Christian Tetzlaff and Dr. Tomas Kulvicius for helpful discussions. This work is supported by Chinese Natural Science Foundation with 31601145, the Fundamental Research Funds for the Central Universities, and the Federal Ministry of Education and Research （BMBF） Germany to the Goettingen Bernstein Center for Computational Neuroscience Project D1. Y.L. conceived the experiment（s）, Z.Z. and Y.L. conducted the experiment（s）, Y.L. and Z.Z. analyzed the results, Y.L. wrote the paper. All authors reviewed the manuscript. The authors declare no competing interest.

摘　　要：This study addresses the fundamental principle of inter-synaptic interactions in synaptic cross-talk through homosynaptic and heterosynaptic plasticity by studying the intrinsic calcium signaling dynamics in spines. Beyond the calcium influx into synapse through voltage gated calcium channels （VGCCs） and N-methyl-D-aspartate （NNMDA） receptors, the function of calcium released from internal store in mediating inter-synaptic cross-talk has barely been modeled. This work investigates how different sources of calcium contribute to inter-synaptic cross-talk and synaptic clustering. Based on experimental observations, we developed a mathematical model in one dimensional system with uniform distribution of spines with the connected dendrite. We modeled the biophysical process of calcium induced calcium release （CICR） in the dendritic smooth endoplasmic reticulum （SER）. Our model compared distinct roles of calcium diffusion, back propagated action potentials （bAPs） and CICR played in synaptic clustering and inter-synaptic cross-talk. The simulation result demonstrated that calcium signal extruded from spine into dendrite requires amplification by CICR before invading neighboring spines to induce plasticity. Our model predicted that initial calcium concentration in SER may discriminate between different types of neuronal activity and induce completely different synaptic potentiation and depression.

关 键 词：Heterosynaptic plasticity calcium dynamics back propagated action potentials CICR diffusion long-term potentiation （LTP） long-term depression （LTD）. 

分 类 号：O614.231[理学—无机化学]