左归丸治疗骨质疏松症相关机制  

Relevant Mechanisms of Zuoguiwan in Treating Osteoporosis

作　　者：柴毅[1] 樊巧玲[1] CHAI Yi;FAN Qiao-ling(Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学

出　　处：《中国实验方剂学杂志》2018年第17期201-208,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81573874)

摘　　要：左归丸是中医经典方剂之一，为“阳中求阴”的代表方，具有滋肾补阴的功效和纯补无泻的特点。骨质疏松症是一种以骨量低，骨组织结构破坏，导致骨脆性增加，骨强度下降及骨折风险增加，易发生骨折为特征的全身性骨病，它已成为威胁人类健康的常见疾病之一。中医学有“肾藏精，主骨生髓”的理论，左归丸在治疗骨质疏松症方面有着较好的临床疗效，同时也具有较少的副作用。近年来，针对左归丸治疗骨质疏松症的实验研究数量与日俱增，相关分子以及信号通路的机制研究亦取得一定拓展，特别是左归丸治疗骨质疏松症的相关机制研究陆续涌现。本研究通过整理左归丸治疗骨质疏松症的文献，对其作用机制及信号通路，包括环腺苷酸（cAMP）／蛋白激酶（PKA）／cAMP应答元件结合蛋白（CREB）通路，Notch信号通路，转化生长因子巾，（TGF-卢，）／Smad信号通路，Wnt／卢一链蛋白（卢一catenin）信号通路和丝裂原活化蛋白激酶（MAPK）信号通路等方面做一综述。这些研究表明左归丸治疗骨质疏松症具有多靶点、多途径的干预特点。虽然左归丸治疗骨质疏松症的疗效明确，且对于一些基本的机制研究亦取得一定进展，但仍存在一定的局限性，尚需结合现代最新研究方法和技术对其机制进行更全面更深入的探索。Zuoguiwan is one of classic formulas of traditional Chinese medicine （TCM）, which is represented the method of seeking yin from yang and characterized by the effect of enriching and nourishing kidney Yin and the complete supplement without any drain. Osteoporosis is a systemic bone disease characterized by low bone mass, structural failure of bone tissue, increased bone brittleness, decreased bone strength and increased risk of fracture, and become one of the threatening in human health. TCM believes that kidney contains the essence and kidney governs the bones and engenders marrow, and Zuoguiwan has a better clinical efficacy in treating osteoporosis and fewer side effect. There have been an increasing number of experimental studies in treating osteoporosis with Zuoguiwan, especially for molecule and mechanism of signaling pathway. The objective of this research was to summarize 5 ＇-monophosphate/protein signaling pathways of Zuoguiwan in treating kinase/cAMP response element-binding osteoporosis, including cyclicadenosine 3＇, protein （ cAMP/PKA/CREB ） signalingpathway, Notch signaling pathway, transforming growth factor-beta 1 （TGF-/31） /Smad signaling pathway, Wnt / β-catenin signaling pathway and mitogen-activated protein kinase （MAPK） signaling pathway. This study also confirmed that Zuoguiwan had intervention characteristics of multiple target points and multiple paths. Although the effect and basic mechanisms of Zuoguiwan were proved, there are still some limitations. More comprehensive and in-depth studies shall also be conducted using the latest modern research methods and techniques.

关 键 词：左归丸 骨质疏松症 环腺苷酸(cAMP)/蛋白激酶(PKA)/cAMP应答元件结合蛋白(CREB)信号通路 Notch信号通路 转化生长因子-β1(TGF-β1)/Smad信号通路 Wnt/β-链蛋白(β-catenin)信号通路 丝裂原活化蛋白激酶(MAPK)信号通路 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学]