奥扎格雷钠治疗急性脑血栓形成的用药效果分析与临床评价  

Efficacy analysis and clinical evaluation of Sodium Ozagrel in the treatment of acute cerebral thrombosis

作　　者：董琛[1] DONG Chen(Department of Medicine,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院药事部,100029

出　　处：《中国现代药物应用》2018年第16期6-8,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨奥扎格雷钠治疗急性脑血栓形成的应用效果。方法 100例急性脑血栓形成患者,根据治疗方法不同分为对照组和观察组,各50例。对照组给予丹参粉针剂治疗,观察组给予奥扎格雷钠治疗。比较两组治疗效果。结果观察组患者总有效率为96.00%,显著高于对照组的78.00%,差异具有统计学意义(P<0.05)。治疗前两组血浆粘度、全血粘度、血细胞比容、美国国立卫生院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后观察组血浆粘度、全血粘度、血细胞比容、NIHSS评分优于对照组,差异具有统计学意义(P<0.05)。观察组神经功能缺损降低50%以上时间为(8.11±1.41)d,短于对照组的(12.42±2.25)d,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥扎格雷钠治疗急性脑血栓形成的应用效果确切,可有效改善血液流变学特性,改善患者神经功能,且无严重不良反应,安全有效,值得推广应用。Objective To investigate the application effect of Sodium Ozagrel in the treatment of acute cerebral thrombosis. Methods A total of 100 patients with acute cerebral thrombosis were divided into control group and observation group according to the different treatment methods, 50 cases in each group. The control group was treated with Salvia miltiorrhiza powder for injection, and the observation group was treated with Ozagrel Sodium. The therapeutic effects between the two groups were compared. Results The total effective rate of the observation group was 96.00%, which was significantly higher than 78.00% of the control group, the difference was statistically significant（P0.05）. There were no significant differences in the plasma viscosity, whole blood viscosity, blood cell specific volume and the National Institutes of Health Stroke Scale（NIHSS） before treatment between the two groups（P0.05）. After treatment, the plasma viscosity, whole blood viscosity, blood cell specific volume and NIHSS score of the observation group were significantly better than those of the control group, the differences were statistically significant（P0.05）. The time of reducing the nerve function defect by more than 50% in the observation group was（8.11±1.41） d, which was significantly shorter than（12.42±2.25） d in the control group, the difference was statistically significant（P0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P0.05）. Conclusion The effect of Sodium Ozagrel in the treatment of acute cerebral thrombosis is accurate. It can effectively improve the hemorheological characteristics and the nerve function of patients, and has no serious adverse reactions. It is safe, effective and worth popularizing and applying.

关 键 词：奥扎格雷钠 急性脑血栓形成 用药效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]