醒脑静注射液对高血压脑出血患者外周血NO、IGF-1、MIF水平的影响  

Effect of Xingnaojing Injection on the levels of NO, IGF-1 and MIF in peripheral blood of patients with hypertensive intracerebral hemorrhage

作　　者：赵永耀 ZHAO Yong-yao(The People’ s Hospital of Enping City,Enping 529400,China)

机构地区：[1]恩平市人民医院,529400

出　　处：《中国现代药物应用》2018年第16期78-79,共2页Chinese Journal of Modern Drug Application

摘　　要：目的分析高血压脑出血患者应用醒脑静注射液对一氧化氮(NO)、胰岛素样生长因子-1(IGF-1)、巨噬细胞转移抑制因子(MIF)水平的影响。方法 85例高血压脑出血患者,随机分为对照组(40例)和研究组(45例)。对照组应用常规治疗,研究组应用常规处理联合醒脑静注射液,比较两组患者治疗前后外周血NO、IGF-1、MIF水平以及并发症情况。结果治疗前,两组患者外周血NO、IGF-1、MIF水平比较,差异无统计学意义(P>0.05);治疗后,研究组NO、IGF-1均高于对照组,MIF低于对照组,差异具有统计学意义(P<0.05)。研究组并发症发生率为4.44%,明显低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论高血压脑出血患者应用醒脑静注射液可降低MIF水平,提升NO、IGF-1水平,减少术后并发症。Objective To analyze the effect of Xingnaojing Injection on the levels of nitric oxide（NO）, insulin-like growth factor-1（IGF-1） and macrophage migration inhibitory factor（MIF） in patients with hypertensive intracerebral hemorrhage. Methods A total of 85 patients with hypertensive intracerebral hemorrhage were randomly divided into control group for 40 cases and research group for 45 cases. The control group received conventional therapy, the research group received conventional therapy combined with Xingnaojing Injection. The levels of NO, IGF-1, MIF in peripheral blood before and after treatment and complications were compared between the two groups. Results Before treatment, there were no significant differences in the levels of NO, IGF-1 and MIF in peripheral blood between the two groups（P0.05）. After treatment, the levels of NO and IGF-1 in the research group were significantly higher than those in the control group, and the MIF was significantly lower than that in the control group, the differences were statistically significant（P0.05）. The incidence of complications in the research group was 4.44%, which was significantly lower than 20.00% in the control group, the difference was statistically significant（P0.05）. Conclusion The application of Xingnaojing Injection in patients with hypertensive intracerebral hemorrhage can reduce the MIF level, increase the levels of NO and IGF-1, and reduce postoperative complications.

关 键 词：醒脑静注射液 高血压脑出血 一氧化氮 胰岛素样生长因子-1 巨噬细胞转移抑制因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]