乳腺癌改良根治术患者术后复发转移的多因素分析  

Multivariate analysis of recurrence and metastasis of breast cancer after modified radical mastectomy

作　　者：穆凌光 孟少华[2] 范秀廷 宋爱林[1] Mu Lingguang;Meng Shaohua;Fan Xiuting;Song Ailin(Head,Neck and Breast Department;Second Department of Abdominal Surgery,The First Affilated Hospital of Xingtai Medical College,Hebei Xingtai 054000,China.)

机构地区：[1]邢台医学高等专科学校第一附属医院头颈乳腺科,河北邢台054000 [2]邢台医学高等专科学校第一附属医院腹部外二科,河北邢台054000

出　　处：《现代肿瘤医学》2018年第17期2706-2710,共5页Journal of Modern Oncology

摘　　要：目的:探讨107例乳腺癌患者改良根治术后复发及远处转移的影响因素,为乳腺癌预防及治疗提供理论基础。方法:对2010年1月至2015年1月我院收治的乳腺癌患者术后的临床资料进行回顾性分析,将107例患者分成复发转移组(34例)及非复发转移组(73例),分析各临床病理因素与乳腺癌患者术后复发转移的关系。结果:乳腺癌患者年龄、肿瘤大小、病理类型、腋窝淋巴结转移、激素受体、TAMs、VEGF、MVD、p53蛋白表达、化疗方案、脉管癌栓、S-TK1、S-CD105、GLUT-1及HK-II与术后复发转移密切相关,差异有显著性(P<0.05),而绝经情况与术后复发转移无明显相关,差异无统计学意义(P>0.05);Logistic多因素回归结果表明,年龄、原发肿瘤大小、p53蛋白表达、S-TK1表达是乳腺癌患者复发转移的独立危险因素。结论:年龄、原发肿瘤大小、p53蛋白表达、S-TK1表达与乳腺癌复发转移密切相关,针对影响乳腺癌复发转移的因素,进行综合的预防及治疗,可以降低乳腺癌患者复发转移的风险,提高生存率。Objective： To explore the clinical related factors for recurrence and metastasis of 107 cases breast cancer patients after midified radical mastectomy,providing theoretical basis for clinical prevention and treatment.Methods： The clinical data of 107 cases postoperative patients in our hospital collected from January 2010 to January2015 were analysed retrospectively. The 107 cases patients were divided into recurrence metastasis group（ 34 cases）and non recurrence metastasis group（ 73 cases）. Analysing the relationship of between different clinical factors with recurrence and metastasis of breast cancer. Results： The recurrence and metastasis of breast cancer was significantly related with patient＇s ages,tumor sizes,pathological types,axillary lymph node metastasis,estrogen receptor,TAMs,VEGF,MVD,p53 protein,chemotherapies,vascular tumor emboli,S-TK1,S-CD105,GLUT-1 and HK-II（ P〈0. 05）,and was not significantly related with menopausal status（ P〈0. 05）. Logistic regression analysis showed that patient＇s ages,tumor sizes,were the independent risk factors of recurrence and metastasis of breast cancer patients（ P〈0. 05）. Conclusion： Patient＇s ages,tumor sizes,p53 protein and S-TK1 were significantly related with recurrence and metastasis of breast cancer. Comprehensive treatment and prevention were given based on the factors influencing recurrence and metastasis of breast cancer to reduce the risk of recurrence and metastasis and increase survival rate.

关 键 词：乳腺癌 改良根治术 复发 转移 

分 类 号：R737.9[医药卫生—肿瘤]