口腔癌患者手术前后T细胞亚群、T细胞内细胞因子及免疫球蛋白的检测分析  

Detection and analysis of T cell subsets,T cell cytokine and immunoglobulin in patients with oral cancer before and after operation

作　　者：李斌 廖湘凌[1] 隋晶 王敏娜[1] LI Bin;LIAO Xiang-ling;SUI Jing;WANG Min-na(Department of Stomatology,Beijing Luhe Hospital Affiliated to Capital Medical University,Beijing 101100,China)

机构地区：[1]首都医科大学附属北京潞河医院口腔科,北京101100

出　　处：《海南医学院学报》2018年第16期1486-1489,共4页Journal of Hainan Medical University

基　　金：北京市科学技术计划项目(Z141100004914001)~~

摘　　要：目的:探讨口腔癌患者手术前后T细胞亚群、T细胞内细胞因子及免疫球蛋白的水平变化。方法:选取2017年1~12月我院收治的40例口腔癌患者作为观察组,选取同期于我院体检的40例健康志愿者作为对照组,检测观察组手术前后T细胞亚群、T细胞内细胞因子及免疫球蛋白的水平变化,并与对照组做比较分析。结果:观察组手术前CD3^+、CD4^+、CD4^+/CD8^+低于对照组,CD8^+高于对照组,差异均有统计学意义(P<0.05);观察组手术后CD3^+、CD4^+、CD4^+/CD8^+分别为(64.98±3.88)%、(42.40±3.53)%、(1.56±0.41),均较手术前升高(P<0.05),但仍低于对照组(P<0.05);观察组手术后CD8^+为(27.25±3.54)%,较手术前降低(P<0.05),但仍高于对照组(P<0.05)。观察组手术前INF-γ^+、CD4^+/INF-γ^+、IL-2^+、CD4^+/IL-2^+均低于对照组,差异均有统计学意义(P<0.05);观察组手术后INF-γ^+、CD4^+/INF-γ^+、IL-2^+、CD4^+/IL-2^+分别为(0.15±0.06)%、(0.07±0.03)%、(0.47±0.13)%、(0.16±0.11)%,均较手术前升高(P<0.05),但仍低于对照组(P<0.05)。观察组手术前、手术后IgA、IgG分别为(2.01±0.13)、(1.81±0.12)、(10.53±3.12)、(8.41±2.01)g/L,均较对照组升高,差异有统计学意义(P<0.05);观察组手术前后IgA、IgG、IgM均无显著变化(P>0.05)。结论:手术可有效改善口腔癌患者T淋巴细胞亚群及T细胞内细胞因子水平,对提高免疫功能具有积极的促进作用。Objective：To investigate the changes of T cell subsets,T cell cytokine and immunoglobulin in patients with oral cancer before and after operation.Methods：40 cases of oral cancer treated in our hospital from January 2017 to December2017 were selected as the observation group,and 40 healthy volunteers in our hospital were selected as the control group.The levels of T cell subsets,T cell cytokine and immunoglobulin in the observation group before and after operation were detected and compared with those in the control group.Results：The CD3^＋,CD4^＋and CD4^＋/CD8^＋of the observation group before operation were lower than those of the control group,and CD8^＋was higher than that of the control group,the differences were statistically significant（P〈0.05）.The CD3^＋,CD4^＋and CD4^＋/CD8^＋after operation in the observation group were（64.98±3.88）%,（42.40±3.53）%and（1.56±0.41）respectively,which were all higher than those before the operation（P〈0.05）,but still lower than those in the control group（P〈0.05）.The CD8^＋of the observation group was（27.25 ± 3.54）% lower than that before operation（P〈0.05）,but it was still higher than that of the control group（P〈0.05）.In the observation group,the levels of INF-γ^＋,CD4^＋/INF-γ^＋,IL-2^＋,and CD4^＋/IL-2^＋before operation were lower in the observation group than those in the control group（P〈0.05）.In the observation group,INF-γ^＋,CD4^＋/INF-γ^＋,IL-2^＋,and CD4^＋/IL-2^＋after surgery were（0.15±0.06）%,（0.07±0.03）%,（0.47±0.13）%,（0.16 ± 0.11）%,were higher than those before surgery（P〈0.05）,but still lower than those in the control group（P〈0.05）.The IgA and IgG before and after the surgery in the observation group were（2.01±0.13）g/L,（1.81±0.12）g/L,（10.53±3.12）g/L,and（8.41±2.01）g/L,respectively,compared with the control group,the difference was statistically significant（P〈0.05）.There was no significant change in IgA,IgG and IgM in the obser

关 键 词：口腔癌 手术 T细胞亚群 T细胞内细胞因子 免疫球蛋白 

分 类 号：R739.8[医药卫生—肿瘤]