桂枝茯苓胶囊对子宫肌瘤患者性激素水平及肿瘤标志物的影响  

Effect of Guizhi Fuling Capsule on sex hormone level and tumor markers in patients with uterine fibroids

作　　者：赵娟娟[1] 管付娟 ZHAO Juan-juan;GUAN Fu-juan(Department of Obstetrics and Gynecology,Jingzhou Public Security County people＇s Hospital,Hubei,Jingzhou 434300,China)

机构地区：[1]湖北省荆州市公安县人民医院妇产科,湖北荆州434300

出　　处：《海南医学院学报》2018年第16期1506-1509,共4页Journal of Hainan Medical University

基　　金：湖北省荆州市科技攻关项目(20152EF3-1)~~

摘　　要：目的:探讨桂枝茯苓胶囊对子宫肌瘤患者性激素及肿瘤标志物的影响,并观察其临床疗效。方法:选择2016年8月~2017年8月我院收治的120例子宫肌瘤患者,依据就诊顺序分为观察组和对照组,各60例。对照组给予米非司酮治疗,观察组给予米非司酮联合桂枝茯苓胶囊治疗。比较两组患者治疗前后血红蛋白、血管内皮生长因子(VEGF)、性激素、肿瘤标志物及炎症因子水平的变化。结果:治疗前,两组患者血红蛋白、VEGF、性激素、肿瘤标志物及炎症因子水平无明显差异(P>0.05)。治疗后,两组患者血红蛋白水平均显著上升,VEGF,性激素卵泡生成激素(follicle-stimulating hormone,FSH)、黄体生成激素(luteinising Hormone,LH)及雌二醇(estradiol,E2),肿瘤标志物人附睾蛋白4(humanepididymisprotein4,HE4)、癌抗原125(cancer antigen 125,CA125),炎症因子肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和γ-干扰素(interferon-γ,IFN-γ)水平均显著下降(P均<0.05)。观察组血红蛋白水平[(117.09±11.51)g/L]高于对照组,VEGF水平[(0.69±0.06)pg/mL]低于对照组。观察组患者性激素FSH、LH及E2水平[分别为(15.87±1.56)U/L、(10.69±1.06)U/L和(4.95±0.51)pmol/L]低于对照组。观察组患者HE4、CA125、TNF-α和IFN-γ水平[分别为(52.47±5.24)pmol/L、(15.46±1.53)U/mL、(40.41±4.05)和(16.72±1.62)pg/mL]低于对照组(P<0.05)。结论:桂枝茯苓胶囊能显著改善患者性激素和肿瘤标志物水平,缓解炎症应激,提高治疗效果。Objective：To investigate the effect of Guizhi Fuling Capsule on sex hormones and tumor markers in patients with uterine fibroids,and observe its clinical efficacy.Methods：The 120 patients with uterine fibroids who were treated in our hospital from August 2016 to August 2017 were selected according to the order of treatment and divided into observation group and control group,60 cases each.Mifepristone was administered to the control group and mifepristone combined with Guizhi Fuling Capsules was administered to the observation group.The levels of hemoglobin,vascular endothelial growth factor（VEGF）,sex hormones,tumor markers,and inflammatory factors before and after treatment were compared between the two groups.Result：The levels of hemoglobin,vascular endothelial growth factor（VEGF）,sex hormones,tumor markers,and inflammatory factors before and after treatment were compared between the two groups.After treatment,hemoglobin levels increased significantly in the two groups,VEGF,sex hormones FSH,LH and E2,tumor markers HE4,CA125,inflammatory cytokines TNF-αand IFN-γlevels decreased significantly（P〈0.05）.The hemoglobin level of the observation group was（117.09±11.51）g/L higher than that of the control group,and the level of VEGF was（0.69±0.06）pg/mL lower than that of the control group.The levels of sex hormone FSH,LH and E2 in the observation group were（15.87±1.56）U/L,（10.69±1.06）U/L and（4.95±0.51）pmol/L lower than those of the control group.The levels of HE4,CA125,TNF-αand IFN-γgamma in the observation group were（52.47±5.24）pmol/L,（15.46±1.53）U/mL,（40.41±4.05）and（16.72±1.62）pg/mL lower than those of the control group（P〈0.05）.Conclusion：Guizhi Fuling Capsule can significantly improve the level of sex hormones and tumor markers,relieve inflammatory stress and improve the therapeutic effect.

关 键 词：桂枝茯苓胶囊 子宫肌瘤 性激素 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]