脑卒中后抑郁病人白细胞介素-6、白细胞介素-8、同型胱氨酸水平与认知功能关系的研究  

The association between cognitive function and the serum levels of interleukin-6,interleukin-8 and homocystine in past-stroke depression patients

作　　者：李研[1] 孙瑞坦[1] 张艳丽[1] 胡迪[1] 朴翔宇 LI Yan;SUN Rui-tan;ZHANG Yan-li;HU Di(Department of Neurology,The Zhongshan Hospital Affiliated to Dalian University,Dalian Liaoning 116001,China)

机构地区：[1]大连大学附属中山医院神经内一科,辽宁大连116001 [2]不详

出　　处：《蚌埠医学院学报》2018年第6期749-752,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨脑卒中后抑郁病人白细胞介素(IL)-6、IL-8、同型胱氨酸(Hcy)水平与认知功能的关系。方法:收集200例脑卒中后抑郁病人,使用简易智能量表(MMSE)对上述病人进行认知能力的检测,使用向后迭代法对常见易感因素进行筛选,建立逻辑斯特模型,将筛选后因素带入模型,进行认知功能与IL-6、IL-8、Hcy水平的相关分析。结果:性别、年龄、患抑郁时间、术中麻醉剂用量、术中失血量、手术时间、出院时间、有无心理疾病病史、不良生活习惯及IL-6、IL-8、Hcy水平均与认知功能减退相关。Hcy、IL-6、IL-8水平的权重较高,分别为2.485、2.547、2.641。结论:脑卒中后抑郁病人的IL-6、IL-8、Hcy水平与其认知功能出现下降的可能性甚至认知水平下降的程度均有一定的相关性。Objective： To investigate the relationships between the levels of interleukin（ IL）-6,IL-8,homocystine（ Hcy） and cognitive function in patients with post-stroke depression. Methods： The cognitive abilities of 200 patients with post-stroke depression were detected using the mini-mental state examination（ MMSE）. The logic ST model was established by the backward iteration method for screening common susceptible factors. The correlations between the levels of IL-6,IL-8 and Hcy,and cognitive function were analyzed.Results： The gender,age,blood loss,depression time,intraoperative anesthetic dosage,intraoperative bleeding,operation time,discharge time,mental disease,bad living habit,and levels of IL-6,IL-8 and Hcy were associated with the cognitive function declining. The weighting coefficients of Hcy,IL-6 and IL-8 were higher（ 2. 485,2. 547 and 2. 641,respectively）. Conclusions： The levels of IL-6,IL-8 and Hcy in patients with post-stroke depression maybe play a certain role in cognitive declining.

关 键 词：脑卒中 抑郁 白细胞介素-6 白细胞介素-8 同型胱氨酸 认知功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]