铁死亡的机制及其在相关疾病中的意义  

Mechanism of ferroptosis and its significance in the related diseases

作　　者：兰斌 龚盛强 成绍武[1] 贺超[1] 廖君[2] 葛金文[1] 王国佐[1] LAN Bin;GONG Sheng-qiang;CHENG Shao-wu;HE Chao;LIAO Jun;GE Jin-wen;WANG Guo-zuo(Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases;School of Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室,湖南长沙410208 [2]湖南中医药大学医学院,湖南长沙410208

出　　处：《基础医学与临床》2018年第9期1337-1341,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81774033);国家自然科学基金青年项目(81202794);湖南省教育厅科研项目(16B191);湖南省教育厅优秀博士学位论文获得者科研项目(YB2016B030)

摘　　要：铁死亡是近年发现的一种铁依赖性脂质过氧化和活性氧(ROS)诱导的调节性细胞死亡,在细胞形态特征和生化指标等方面与细胞凋亡、自噬和程序性坏死等死亡方式存在较大差别,并显著涉及肿瘤、神经系统和缺血再灌注损伤等多种临床疾病。深入认识铁死亡可为相关疾病的防治提供新的思路。It is found in recent years that ferroptosis is a kind of regulatory cell death induced by iron dependent lipid peroxidation and reactive oxygen species（ ROS）. There are significant differences in cell apoptosis,autophagy,and programmed bad death in cell morphology and biochemical indexes. It is involved in many clinical diseases such as tumor,nervous system illness and ischemia-reperfusion injury. Understanding ferroptosis in depth may provide new approaches for prevention and treatment of related diseases.

关 键 词：铁死亡 铁代谢 脂质过氧化 活性氧 

分 类 号：R363[医药卫生—病理学]