Melatonin for the treatment of spinal cord injury  

作　　者：Yan Zhang Wen-Xiu Zhang Yan-Jun Zhang Ya-Dong Liu Zong-Jian Liu Qi-Chao Wu Yun Guan Xue-Ming Chen 

机构地区：[1]Central Laboratory,Beijing Luhe Hospital,Capital Medical University [2]Department of Orthopedics,Beijing Luhe Hospital,Capital Medical University [3]Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University [4]Department of Neurological Surgery,Johns Hopkins University

出　　处：《Neural Regeneration Research》2018年第10期1685-1692,共8页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81671161(to ZJL)

摘　　要：Spinal cord injury（SCI） from trauma or disease severely impairs sensory and motor function. Neurorehabilitation after SCI is a complex medical process that focuses on improving neurologic function and repairing damaged connections in the central nervous system. An increasing number of preclinical studies suggest that melatonin may be useful for the treatment of SCI. Melatonin is an indolamine that is primarily secreted by the pineal gland and known to be regulated by photoperiodicity. However, it is also a versatile hormone with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. Here, we review the neuroprotective properties of melatonin and the potential mechanisms by which it might be beneficial in the treatment of SCI. We also describe therapies that combine melatonin with exercise, oxytetracycline, and dexamethasone to attenuate the secondary injury after SCI and limit potential side effects. Finally, we discuss how injury at different spinal levels may differentially affect the secretion of melatonin.Spinal cord injury（SCI） from trauma or disease severely impairs sensory and motor function. Neurorehabilitation after SCI is a complex medical process that focuses on improving neurologic function and repairing damaged connections in the central nervous system. An increasing number of preclinical studies suggest that melatonin may be useful for the treatment of SCI. Melatonin is an indolamine that is primarily secreted by the pineal gland and known to be regulated by photoperiodicity. However, it is also a versatile hormone with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. Here, we review the neuroprotective properties of melatonin and the potential mechanisms by which it might be beneficial in the treatment of SCI. We also describe therapies that combine melatonin with exercise, oxytetracycline, and dexamethasone to attenuate the secondary injury after SCI and limit potential side effects. Finally, we discuss how injury at different spinal levels may differentially affect the secretion of melatonin.

关 键 词：spinal cord injury melatonin secondary damage NEUROPROTECTION antioxidative antiapoptotic ANTI-INFLAMMATORY synergistic effects neural regeneration 

分 类 号：R651.2[医药卫生—外科学]