小剂量CAG与MA方案治疗老年急性髓系白血病的临床疗效对比  

The Clinical Efficacy of Small Dose CAG Program in Comparison with MA Program in Senile Patients with Acute Myeloid Leukemia

作　　者：王丽娟 吴希锋 孙玲[1] 庄伟[2] 宋强[3] WANG Li-Juan;WU Xi-Feng;SUN Ling;ZHUANG Wei;SONG Qiang(Department of hematology;Department of laboratory Examination,Laiwu People＇s Hospital,Laiwu 271100,Shandong Province,Chi-na;Department of hematology,Qilu Hospital,Shandong University,Jinan 250012,Shandong Province,China)

机构地区：[1]莱芜市人民医院血液科,山东莱芜271100 [2]莱芜市人民医院检验科,山东莱芜271100 [3]山东大学齐鲁医院血液科,山东济南250012

出　　处：《中国实验血液学杂志》2018年第4期1050-1055,共6页Journal of Experimental Hematology

摘　　要：目的:比较小剂量CAG与MA方案治疗老年急性髓系白血病的临床疗效。方法:回顾分析2012年9月至2016年9月本院收治的83例老年急性髓性白血病患者的临床资料,依据化疗方案不同,分为CAG和MA 2组;CAG组36例患者给予小剂量CAG方案,而MA组47例给予MA方案。对比研究2组患者的临床疗效(完全缓解率、部分缓解率、未缓解率)、血清细胞因子(IL-6,IL-17,TGF-β)、不良反应(骨髓抑制、感染、胃肠道反应、出血)、化疗预后指标(2年内死亡率、中位生存时间、最短生存时间)。结果:在临床疗效方面,CAG组完全缓解率、部分缓解率与MA组相比,差异无统计学差异(P>0.05);CAG组血清细胞因子(IL-6,IL-17,TGF-β)水平明显高于MA组(P<0.05);CAG组骨髓抑制、感染、出血等不良反应发生率明显低于MA组(P<0.05),2组胃肠道反应发生率无统计学差异;2组的2年内生存率、中位生存时间和最短生存时间无明显统计学差异(P>0.05)。结论:对老年急性髓系白血病患者,相比传统化疗术式MA方案,小剂量CAG方案能保证临床疗效和患者生存率,减少不良反应发生,优势显著。Objective： To compare the clinical efficacy of small dose CAG regimen and MA regimen in the senile patients with acute myeloid leukemia（ AML）. Methods： The clinical data of 83 senile patients with AML from Sep.2012 to Sep. 2016 in our Hospital were analyzed retrospectively. According to the chemotherapy regimens,the patients were divided into CAG group and MA group; 36 patients in CAG group were treated with small dose CAG,while 47 patients in MA group were treated with MA. The curative efficiency（ CR rate,PR rate,NR rate and OR rate）,side effect（ myelosuppression,infection,intestinal discomfort and hemorrage）,serum cytokines（ IL-6,IL-17,TGF-β）,and prognosis（ survival rate in 2 years,MST and SST） were observed,compared and studied in these 2 group. Results： The curative efficiency,CR rate and PR rate of the CAG group were not significantly different from that of the MA group（ P〈0. 05）. The side effect in CAG group was significantly lower than that in the MA group（ P〈0. 05）. The levels of serum cytokines of the MA group were lower than those of the CAG group. Additionally,the prognosis was not significantly different between 2 groups（ P〈0. 05）. Conclusion： For senile patients with acute myeloid leukemia,compared with traditional MA regimen,the small dose CAG has a certain curative efficacy and survival rate,and the incidence of side effect reduced. Therefore,the small dose CAG is superior to MA for the senile patients with acute myeloid leukemia.

关 键 词：小剂量CAG方案 MA方案 老年急性髓性白血病 临床疗效对比 

分 类 号：R733.71[医药卫生—肿瘤]