POEMS综合征治疗研究最新进展  

Progress in Treatment of POEMS Syndrome

作　　者：樊文静[1,2] 吴涛 白海[1] FAN Wen-Jing;WU Tao;BAI Hai(Department of Hematology,Center for Hematologic Diseases of Chinese PLA,Lanzhou Military Command General Hospital,Lanzhou 730050,Gansu Proince,China;The Second Clinical Medical College of Lanzhou University,Lanzhou 730030,Gansu Proince,China)

机构地区：[1]兰州军区兰州总医院全军血液病专科中心,甘肃兰州730050 [2]兰州大学第二临床医学院,甘肃兰州730030

出　　处：《中国实验血液学杂志》2018年第4期1225-1229,共5页Journal of Experimental Hematology

摘　　要：POEMS综合征是一种罕见的浆细胞异常增多的多系统受累的副瘤综合征,治疗大多为大剂量化疗后干细胞移植。近几年,为了提高POEMS综合征患者的有效性和安全性,出现了更多的试验治疗方案,如免疫调节剂、烷化剂和细胞因子诱导的杀伤细胞等。来那度胺对于难治复发的POEMS综合征以及内分泌病变明显的患者效果明显,细胞因子诱导的杀伤细胞也是一种安全有效的治疗POEMS综合征的方案。本文分别阐述免疫调节剂、烷化剂、细胞因子诱导的杀伤细胞、干细胞移植、蛋白酶体抑制剂以及单克隆抗体对于POEMS综合征治疗的有效性和安全性,就POEMS综合征治疗的最新临床研究进展作一综述。POEMS syndrome is a rare multiple organ involvement of the parasympathetic syndrome associated with abnormal plasma cells, mostly with high-dose chemotherapy and stem cell transplantation for the treatment. Recently,more treatment attempts to treat POEMS syndrome have been utilized so as to improve the efficacy and safety for the patients with POEMS syndrome, such as immunomodulator, alkylating agent, cytokine-induced killer cells and so on. Lenalidomide has a significant effect on relapse/refractory POEMS syndrome and patients with endocrinopathy.Cytokine-induced killer cells are also a safe and effective regimen for the treatment of POEMS syndrome. This review described the efficacy and safety of immunomodulatos, alkylators, cytokine-induced killer cells, ASCT, proteasome inhibitors and monoclonal antibodies for POEMS syndrome, and the newest clinical research and progress of POEMS syndrome ware summarized briefly.

关 键 词：POEMS综合征 来那度胺 细胞因子诱导的杀伤细胞 干细胞移植 美法仑 

分 类 号：R745[医药卫生—神经病学与精神病学] R733[医药卫生—临床医学]