首发未服药精神分裂症患者血清核心蛋白多糖水平与认知功能的关系  

Correlation of the serum decorin levels and the cognitive function in first-episode drug.native patientswith schizophrenia

作　　者：玄燕 陈松[1] 安会梅[1] 王志仁[1] 杨甫德[1] 谭淑平[1] 杨贵刚[1] 张向阳[1] 周东丰[2] 谭云龙[1] Xuan Yan, Chen Song, An Huimei, Wang Zhiren, Yang Fude, Tan Shuping, Yang Guigang , Zhang Xiangyang , Zhou Dongfeng , Tan Yunlong(Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China ; Psychiatry Department, Peking University Sixth Hospital （ Institute of Mental Health ） , Beijing 100191, China)

机构地区：[1]北京大学回龙观临床医学院精神科,北京100096 [2]北京大学第六医院北京大学精神卫生研究所精神科,北京100096

出　　处：《中华行为医学与脑科学杂志》2018年第8期744-748,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：北京市医院管理局＂登峰＂计划项目基金（DFL20151901）;北京市医院管理局临床技术项目基金（XMLX01513）

摘　　要：目的 通过分析首发未服药精神分裂症患者血清核心蛋白多糖（Decorin,DCN）水平与认知损伤的关系,探讨DCN在精神分裂症发病机制中可能的作用.方法 纳入首发未服药的精神分裂症患者30例（精神分裂症组）;同期纳入年龄、性别与疾病组匹配的健康对照30名（对照组）.采用阳性和阴性症状量表（PANSS）评估精神分裂症组的精神病理症状,MATRICS共识认知成套测验（MCCB）评估所有研究对象的认知功能;采用酶联免疫吸附法（ELISA）检测所有被试的血清DCN水平.结果 精神分裂症组血清DCN水平显著低于对照组[（1.56± 0.96） ng/ml,（3.35± 1.71） ng/ml,P＜0.01];血清DCN水平与PANSS阳性症状评分呈正相关（r=0.41,P=0.03）,与MCCB言语流畅度（r=-0.40,P=0.04）、言语记忆（r=-0.42,P=0.02）、视觉记忆（r=-0.39,P=0.04）、持续操作（r=-0.41,P=0.03）、符号编码（r=-0.49,P=0.01）、连线T分（r=-0.42,P=0.02）及总分（r=-0.55,P＜0.01）呈负相关;控制年龄、性别和受教育程度后,上述相关关系仍然存在.结论 首发未服药精神分裂症患者血清DCN水平与认知功能相关;DCN可能参与了精神分裂症疾病的发生.Objective To explore the role of decorin （DCN） on the pathogenesis of schizophrenia by analyzing the correlation between serum DCN levels and cognitive impairment in the first-episode drug-native （FEDN） patients with schizophrenia.Methods 30 FEDN patients with schizophrenia and 30 age and gender matched healthy volunteers （control group） were enrolled.The psychopathological symptoms were assessed by the PANSS and the cognitive function was assessed by the MATRICS Consensus Cognitive Battery （MCCB）.The serum DCN levels were measured by using enzyme linked immunosorbent assay （ELISA）.The difference of DCN levels between the two groups were compared and the correlations of serum DCN levels to age,sex,the score of the MCCB and PANSS were analyzed.Results The serum DCN levels were lower in patients with schizophrenia than those in control group （（1.56±0.96） ng/ml vs （3.35± 1.71） ng/ml,P〈 0.01）.The serum DCN levels were positively correlated with the positive symptom score （r=0.41,P=0.03）.The serum DCN levels were significantly negatively correlated with MCCB verbal fluency （r =-0.40,P =0.04）,verbal memory （r=-0.42,P=0.02）,visual memory （r=-0.39,P=0.04）,continuous operation （r=-0.41,P=0.03）,encoding symbols （r=-0.49,P=0.01）,T line （r=-0.42,P=0.02） and total score （r=-0.55,P〈0.01）,and after controlling the age and gender,the relationships were still exist.Conclusion It suggests that serum DCN levels are associated with cognitive function in first-episode patients with schizophrenia,and that DCN may be involved in the pathogenesis of schizophrenia.

关 键 词：精神分裂症 核心蛋白多糖 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]