微小RNA-373在肿瘤中的作用  

Role of microRNA-373 in tumor

作　　者：沈凯 邵芳[1] 冯同保[2] 戚春建[1] Shen Kai;Shao Fang;Feng Tongbao;Qi Chunfian(Tumor Research Center,Changzhou Second People＇s Hospital,Nanjing Medical University,Changzhou 213000,China)

机构地区：[1]南京医科大学附属常州市第二人民医院肿瘤研究所,213000 [2]南京医科大学附属常州市第二人民医院检验科,213000

出　　处：《国际肿瘤学杂志》2018年第6期355-357,共3页Journal of International Oncology

基　　金：国家自然科学基金（31501942、31601156）

摘　　要：微小RNA是参与转录后基因表达调控的非编码小RNA，在不同肿瘤中起抑癌或促癌作用。微小RNA-373是微小RNA-520／373家族成员之一，它参与肿瘤的缺氧反应和DNA损伤修复。微小RNA-373在乳腺癌、胶质瘤、肺癌、前列腺癌等肿瘤中异常表达，可能在其发展过程特别是肿瘤入侵和迁移中起重要作用。MicroRNAs are non-coding small RNAs that participate in the regulation of post transcrip- tional gene expression. MicroRNAs play the roles of inhibiting cancer or promoting cancer in different tumors. MicroRNA-373 is one of the members of the microRNA-520/373 family, which is involved in cancer anoxic response and DNA damage repair. MicroRNA-373 is abnormal expressed in breast cancer, glioma, lung cancer, prostate cancer and other tumors, which may play an important role in tumor development process, especially in tumor invasion and migration.

关 键 词：肿瘤 微RNAS 肿瘤转移 基因表达调控 

分 类 号：R730.2[医药卫生—肿瘤]