加减肉苁蓉汤联合乳果糖口服液治疗便秘型肠易激综合征临床疗效及对其生活质量的影响  

Clinical efficacy of modified cistanche decoction combined with lactulose oral liquid in the treatment of constipated irritable bowel syndrome and its impact on quality of life

作　　者：廖春林 卢俊明[2] Liao Chunlin;Lu Junming(Department of Chinese Medicine,the People＇s Hospital of Qingyuan County,Zhejiang 323800,Chin;Department of Chinese Medicine,Lishui Hospital of Traditional Chinese Medicine,Lishui,Zhejiang 323000,China)

机构地区：[1]浙江省庆元县人民医院中医科,323800 [2]丽水市中医院中医科,浙江省丽水323000

出　　处：《中国基层医药》2018年第15期1938-1942,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨便秘型肠易激综合征患者采用加减肉苁蓉汤联合乳果糖口服液治疗临床疗效,并观察其对患者生活质量的改善作用.方法 回顾性分析2013年6月至2016年6月庆元县人民医院便秘型肠易激综合征的76例患者临床诊治情况,其中将乳果糖口服液治疗者作为对照组,在对照组治疗基础上中药加减肉苁蓉汤治疗者作为治疗组,对照组和治疗组各38例.通过对这两组临床的医疗效果或者产生的不良反应进行分析,然后对这两组治疗前、后中医证候积分、生活质量进行评分.结果 治疗组治疗后各项中医证候积分均明显低于对照组（t＝2.87、3.17、2.68、3.75、4.27、3.83、5.02、4.40、2.48,P＝0.00、0.00、0.00、0.00、0.00、0.00、0.00、0.00、0.01）,各项生活质量维度评分明显高于对照组（t＝3.10、3.44、3.36、3.58、4.51、3.32、2.95、2.89,P＝0.00、0.00、0.00、0.00、0.00、0.00、0.00、0.00）,两组治疗后各项中医证候积分明显低于治疗前（对照组：t＝4.28、5.11、4.07、6.38、5.06、2.11、7.32、4.38、20.22,P＝0.00、0.00、0.00、0.00、0.00、0.00、0.04、0.00、0.00;治疗组：t＝7.81、9.86、7.68、13.76、9.31、6.57、14.63、9.62、7.36,P＝0.00、0.00、0.00、0.00、0.00、0.00、0.00、0.00、0.00）,各项生活质量维度评分明显高于治疗前（对照组：t＝2.85、3.59、2.58、2.60、4.01、4.88、3.05、2.36,P＝0.00、0.00、0.01、0.01、0.00、0.00、0.00、0.02;治疗组：t＝5.57、6.72、6.60、6.40、7.74、7.63、5.84、6.30,P＝0.00、0.00、0.00、0.00、0.00、0.00、0.00、0.00）.治疗组治疗总有效率86.84%,明显高于对照组65.79%（χ2＝7.13,P＝0.02）;治疗期间未发现明显的不良反应.结论 加减肉苁蓉汤联合乳果糖口服液对于便秘型肠易激综合征患者具有具有十分明显的疗效,且有助于改善患者生活质量.Objective To investigate the clinical efficacy of modified cistanche decoction combined with lactulose oral liquid in the treatment of patients with constipation -type irritable bowel syndrome ,and to observe its effect on improving the quality of life of patients.Methods From June 2013 to June 2016,the clinical diagnosis and treatment of 76 patients with constipation-predominant irritable bowel syndrome in the People＇s Hospital of Qingyuan County were retrospectively analyzed.Among them,lactulose oral liquid was used in the control group.On the basis of the control group,cistanche soup was given in the treatment group ,the control group and the treatment group had 38 cases.The clinical effects,adverse reactions were analyzed ,and before and after treatment ,TCM syndrome score and quality of life score were recorded.Results After treatment,the TCM syndrome scores of the treatment group were significantly lower than those of the control group （t＝2.87,3.17,2.68,3.75,4.27,3.83,5.02,4.40,2.48, P＝0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.01）,the quality of life dimensions scores of the treatment group were significantly higher than those of the control group （t＝3.10,3.44,3.36,3.58,4.51,3.32,2.95,2.89, P＝0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00）.However,after treatment,the scores of TCM syndromes in both two groups were significantly lower than those before treatment （ control group：t ＝4.28,5.11,4.07,6.38,5.06, 2.11,7.32,4.38,20.22,P＝0.00,0.00,0.00,0.00,0.00,0.00,0.04,0.00,0.00;treatment group：t ＝7.81, 9.86,7.68,13.76,9.31,6.57,14.639.62,7.36,P＝0.00,0.00,0.00,0.00）.The scores of all dimensions of life quality were significantly higher than those before treatment （control group：t＝2.85,3.59,2.58,2.60,4.01,4.88, 3.05,2.36,P＝0.00,0.00,0.01,0.01,0.00,0.00,0.00,0.02;treatment group：t＝5.57,6.72,6.60,6.40,7.74, 7.63,5.84,6.30,P＝0.00,0.00,0.00,0.00,0.00,0.00,0.00,0.00）.The total effective rate of the treatment group was 86.84%,which was significantly higher than 65.79% of the con

关 键 词：肠易激综合征 生活质量 肉苁蓉属 乳果糖 

分 类 号：R574.4[医药卫生—消化系统]