泮托拉唑治疗消化性溃疡合并出血的临床观察  

Clinical observation of Pantoprazole in the treatment of peptic ulcer complicated with hemorrhage

作　　者：蔡全保 CAI Quan-bao(Department of Internal Medicine,Guangzhou Huangpu District Hospital of Traditional Chinese Medicine,Guangzhou 510700,China)

机构地区：[1]广州市黄埔区中医院内科,510700

出　　处：《中国实用医药》2018年第22期11-13,共3页China Practical Medicine

摘　　要：目的探讨泮托拉唑治疗消化性溃疡合并出血的临床效果。方法 60例消化性溃疡合并出血患者,采用双色球分组法分成对照组和观察组,各30例。在常规治疗基础上,对照组采用奥美拉唑治疗,观察组则采用泮托拉唑治疗。比较两组症状改善情况、疼痛强度、成功止血时间、住院天数及药物不良反应发生情况。结果治疗前两组患者黑便次数、呕血次数及出血量比较,差异无统计学意义(P>0.05);治疗3 d后,观察组黑便次数(0.23±0.14)次/d、呕血次数(0.32±0.10)次/d、出血量(12.62±2.01)ml/d少于对照组的(1.15±0.10)次/d、(1.21±0.15)次/d、(24.52±3.36)ml/d,差异有统计学意义(P<0.05)。治疗前两组疼痛得分比较差异无统计学意义(P>0.05);治疗2、5 d后,观察组疼痛得分低于对照组,差异有统计学意义(P<0.05)。观察组成功止血时间、住院天数短于对照组,差异有统计学意义(P<0.05)。观察组药物不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论奥美拉唑、泮托拉唑对消化性溃疡合并出血有一定的治疗效果,但是泮托拉唑的疗效和安全性更高,值得采用。Objective To investigate the clinical effect of Pantoprazole in the treatment of peptic ulcer complicated with hemorrhage. Methods A total of 60 peptic ulcer patients complicated with hemorrhage were divided into control group and observation group by double color ball grouping method, 30 cases in each group. On the basis of conventional therapy, the control group received Omeprazole for treatment, and the observation group received Pantoprazole for treatment. The symptom improvement, pain intensity, successful hemostasis time, length of stay and adverse drug reactions between the two groups were compared. Results Before treatment, there were no statistically significant differences in the number of black stools, number of hematemesis and bleeding volume between the two groups（P0.05）. After 3 d of treatment, the number of black stools, number of hematemesis and bleeding volume in the observation group were（0.23±0.14） times/d,（0.32±0.10） times/d and（12.62±2.01） ml/d respectively, which were significantly less than（1.15±0.10） times/d,（1.21±0.15） times/d and（24.52±3.36） ml/d in the control group, the differences were statistically significant（P0.05）. Before treatment, there was no statistically significant difference in the pain score between the two groups（P0.05）. After 2 and 5 d of treatment, the pain scores of the observation group were significantly lower than those of the control group, the differences were statistically significant（P0.05）. The successful hemostasis time and length of stay in the observation group were significantly shorter than those in the control group, the differences were statistically significant（P0.05）. The incidence of adverse drug reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant（P0.05）. Conclusion Omeprazole and Pantoprazole show certain effects in the treatment of peptic ulcer complicated with hemorrhage, but Pantoprazole is more effective and sa

关 键 词：消化性溃疡 出血 泮托拉唑 

分 类 号：R573.1[医药卫生—消化系统]