吲哚菁绿联合美蓝示踪乳腺癌前哨淋巴结活检术的远期安全性分析  

The long-term safety of sentinel lymph node biopsy mapped by combination of indocyanine green and methylene blue in breast cancer patients

作　　者：王朝斌[1] 王殊[1] 杨后圃[1] 郭嘉嘉[1] 任欣玫[1] 刘淼[1] 佟富中[1] 曹迎明[1] 周波[1] 刘鹏[1] 程琳[1] 刘宏军[1] 谢菲[1] 王思源[1] Wang Chaobin;Wang Shu;Yang Houpu;Guo Jiafia;Ren Xinmei;Liu Miao;Tong Fuzhong;Cao Yingming;Zhou Bo;Liu Peng;Cheng Lin;Liu Hongjun;Xie Fei;Wang Siyuan(Department of Breast Surgery,Peking University People＇s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院乳腺中心,北京100044

出　　处：《中华普通外科杂志》2018年第8期682-684,共3页Chinese Journal of General Surgery

基　　金：首都卫生发展科研专项项目（2014-24083）;北京大学临床医学＋x青年专项（PKU2018LCXQ004）

摘　　要：目的探讨吲哚菁绿联合美蓝示踪乳腺癌前哨淋巴结活检术的远期安全性。方法198例腋窝临床阴性的乳腺癌患者接受吲哚菁绿联合美蓝双示踪的乳腺癌前哨淋巴结活检术并进行长期随访，分析区域淋巴结复发率、无病生存率、总生存率及上肢水肿发生率。结果中位随访时间70个月，2例患者出现同侧腋窝淋巴结复发，区域淋巴结复发率为1％（2／198），14例患者出现复发转移，6例患者死于乳腺癌远处转移，6年无病生存率为94．4％，总生存率为96．5％。接受电话随访患者中腋窝淋巴结清扫术后上肢水肿发生率为4．5％，前哨淋巴结活检术后上肢水肿发生率为2．5％。结论吲哚菁绿联合美蓝示踪的乳腺癌前哨淋巴结活检术是一种安全可靠的腋窝分期术式。Objective To evaluate the long-term safety of sentinel lymph node biopsy ,napped by combination of indocyanine green and methylene blue in breast cancer patients. Methods 198 breast cancer patients with clinical negative axillary lymph node received sentinel lymph node biopsy mapped by combination of indocyanine green and methylene blue. Patients were followed up and regional lymph node recurrence, disease free survival（DFS） and overall survival（OS） were analyzed. Results After a median follow-up of 70 months, 2 patients had ipsilateral lymph node recurrence with a regional lymph node recurrence rate of 1% （2/198）. 14 patient had recurrence or metastasis and 6 patients died of distant metastasis. The estimated 6 years DFS was 94.4% and OS was 96. 5%. The incidence of arm lymphoedema within patients who received axillary lymph node dissection was 4. 5% and it was 2. 5% in patients who received sentinel lymph node biopsy. Conclusions The sentinel lymph node biopsy mapped by combination of indocyanine green and methylene blue was safe and reliable method for further staging axillary lymph node stastus.

关 键 词：乳腺肿瘤 前哨淋巴结活组织检查 吲哚菁绿 美蓝 

分 类 号：R737.9[医药卫生—肿瘤]