美沙拉嗪与柳氮磺吡啶对溃疡性结肠炎的效果比较分析  

Comparison of Effects of Mesalazine and Sulfasalazine on Ulcerative Colitis

作　　者：刘丹[1] LIU Dan(Jiamusi Central Hospital,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院,黑龙江佳木斯154002

出　　处：《中国医学创新》2018年第23期23-27,共5页Medical Innovation of China

基　　金：黑龙江省卫生厅课题(2010-493)

摘　　要：目的:分析美沙拉嗪与柳氮磺吡啶对溃疡性结肠炎的治疗效果。方法:选取2016年1月-2017年6月本院收治的炎症性肠病患者78例。按照随机数字表法将其分为对照组和观察组,各39例。两组均给予益生菌口服,对照组联用柳氮磺吡啶进行治疗,观察组联用美沙拉嗪进行治疗,均持续治疗30 d。比较两组治疗前后的局部组织积分、症状积分、血常规检测结果及治疗效果、不良反应。结果:观察组治疗总有效率94.87%,显著高于对照组的76.92%(P<0.05);治疗后,两组组织及症状积分均低于治疗前,且观察组均低于对照组,比较差异均有统计学意义(P<0.05);治疗后,两组血常规检查指标水平均优于治疗前,且观察组均优于对照组,比较差异均有统计学意义(P<0.05);但两组不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:美沙拉嗪治疗溃疡性结肠炎的临床效果好于柳氮磺吡啶。Objective：To analyze the effect of Mesalazine and Sulfasalazine on ulcerative colitis. Method：A total of 78 patients with ulcerative colitis treated in our hospital from January 2016 to June 2017 were selected.According to the random number table method,they were divided into control group and observation group,39 cases in each group.They were given probiotics orally,the control group was treated with Sulfasalazine,the observation group was treated with Mesalazine,treated for 30 days.The local tissue integral,symptom score,blood routine test result before and after treatment,therapeutic effect and adverse reaction were compared between the two groups.Result：The total effective rate of treatment in the observation group was 94.87%,which was significantly higher than 76.92% of control group（P〈0.05）.After treatment,the tissue and symptom scores in two groups were lower than those before treatment,and observation group were lower than those of control group,the differences were statistically significant（P〈0.05）.After treatment,the blood routine examination indicators in two groups were better than those before treatment,and observation group were better than those of control group,the differences were statistically significant（P〈0.05）.But the incidence of adverse reaction in two groups were compared,the differences were not statistically significant（P〉0.05）.Conclusion：The clinical effect of Mesalazine treatment of ulcerative colitis is better than Sulfasalazine.

关 键 词：美沙拉嗪 柳氮磺吡啶 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]