CUEDC2在肿瘤中的表达及作用机制的研究进展  

Research Progress in Expression and Mechanism of CUEDC2 in Tumors

作　　者：孙佳鑫 程海东 郝钦[2] 侯明星[2] SUN Jiaxin;CHENG Haidong;HAO Qin;HOU Mingxing(Inner Mongolia Medical University,Hohhot 010050,China;Department of Gastrointestinal Surgery,Inner Mongolia Medical University Affiliated Hospital,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学,呼和浩特010050 [2]内蒙古医科大学附属医院胃肠外科,呼和浩特010050

出　　处：《医学综述》2018年第16期3171-3176,共6页Medical Recapitulate

基　　金：内蒙古医科大学科技百万工联合程项目(YKD2017KJBW[LH]002)

摘　　要：随着医疗技术的不断进步,有关肿瘤的研究也不断地深入,发现CUE结构域2(CUEDC2)可通过泛素蛋白酶体途径促进黄体酮受体降解,抑制乳腺癌的进展。随着学者们的不断研究,发现其也可能通过核因子κB、Janus激酶-信号转导及转录激活因子等信号通路对肿瘤发生发展进行调控,也可通过参与影响沃伯格效应最终影响肿瘤细胞的代谢。CUEDC2在乳腺癌、结直肠癌中高度表达,在肺癌、胶质瘤中则呈现出低表达状态。CUEDC2在不同肿瘤中呈现出差异性表达,根据现有的文献报道,针对CUEDC2参与肿瘤发生发展的具体机制的研究进展进行综述。With the continuous advancement of medical technology,the research on tumors has been continuously deepened. It has been found that CUE domain containing 2（ CUEDC2） can promote the degradation of progesterone receptors and inhibit the progression of breast cancer through the ubiquitin-proteasome pathway. As scholars continue to study,it has been found that they may also regulate the development of tumors through signal pathways such as nuclear factor-κB and Janus kinase-signal transducers and activators of transcription signaling pathways. It can also affect the metabolism of tumor cells ultimately by participating in influencing the Warburg effect. CUEDC2 is highly expressed in breast and colorectal cancers,and shows low expression in lung and gliomas. CUEDC2 shows differential expression in different tumors. Here is to make a review on the research progress on the specific mechanism of CUEDC2 involvement in tumorigenesis according to the existing literature reports.

关 键 词：肿瘤 CUED结构域2 信号转导 肿瘤代谢 

分 类 号：R733[医药卫生—肿瘤]