非病理性乳头溢液患者不同病理类型乳管内病变相对危险因素的回顾性分析  

A retrospective analysis of the risks of intraductal lesions in patients without pathological nipple discharge( PND)

作　　者：柯子瑞 林元强[1] 申磊花 郑丹丹 王可人[1] Ke Zirui;Lin Yuanqiang;Shen Leihua;Zheng Dandan;Wang Keren(China-Japan Union Hospital of Jilin University,Jilin Changchun 130033,China.)

机构地区：[1]吉林大学中日联谊医院,吉林长春130033

出　　处：《现代肿瘤医学》2018年第18期2859-2862,共4页Journal of Modern Oncology

摘　　要：目的:探讨非病理性乳头溢液患者不同病理类型乳管内病变的相对危险因素。方法:回顾性分析2016年4月至2017年2月于吉林大学中日联谊医院乳腺外科行手术治疗的360侧病理诊断为乳管内病变的患病乳房患者的临床病理资料,其中包括病理性乳头溢液(pathological nipple discharge,PND)123侧,非病理性乳头溢液(non-PND)237侧。分析PND组与非PND组的导管内病变的病理类型(乳头状瘤样增生、乳头状瘤、不典型增生、导管内原位癌)构成比差异;再对206例临床病理资料完整的非PND性乳管内病变患者进行单因素分析及多因素Logistic回归分析,分析非PND性乳管内病变不同病理类型的相对危险因素。结果:年龄>50岁、未绝经、结节最大径≤1 cm、超声下有导管扩张、局部血流丰富为非PND性乳管内乳头状瘤的相对危险因素(均P<0.05);年龄>50岁为非PND性乳管上皮非典型增生的相对危险因素(P<0.05);单发结节、绝经状态、局部血流丰富为非PND性导管内原位癌的相对危险因素(均P<0.05)。结论:非PND性乳管内病变具有较高的发病率,通过对其危险因素进行探索可加强对非PND性乳管内病变的重视及早期诊治。Objective： To explore the relative risk factors of different pathological types intraduct lesions in patients with non-pathological nipple discharge.Methods： Retrospective analysis of the clinical and pathological data of the 360 breast cancer cases who had underwent breast surgery in the China-Japan Union Hospital of Jilin University from April 2016 to February 2017.This study includes 123 cases with pathological nipple discharge（ PND） and 237 cases without pathological nipple discharge（ non-PND）.The composition ratio of different pathological types was analyzed between the group with PND and the group without PND.206 cases with full clinnicopathological information were chosen for further analysis.In order to analyze the relative risk factors of intraductal lesion in patients without PND,clinical parameters were evaluated in univariate and multivariate Logistic regression analyses.Results： Older than 50 years old,pre-menopausal,the maximum diameter of nodules is less than 1 cm,duct dilatation under the ultrasound and richness of local blood flow are the relative risk factors of non-PND intraductal papilloma（ P 0.05）.Older than 50 years old is the relative risk factor of non-PND atypical ductal hyperplasia（ P 0.05）.Solitary nodule,postmenopausal and richness of local blood flow are the relative risk factors of non-PND ductal carcinoma in situ（ P 0.05）.Conclusion： Non-PND intraductal lesion has higher morbidity,which cauld be early diagnosed and treated through analysing its risk factors.

关 键 词：病理性乳头溢液 乳管内乳头状瘤样增生(PNH) 乳管内乳头状瘤(IDP) 乳腺导管上皮非典型增生(ADH) 导管内原位癌(DCIS) 相对危险因素 

分 类 号：R737.9[医药卫生—肿瘤]