钙化性腱膜纤维瘤2例临床病理分析  

Clinicopathological analysis of two cases of calcifying aponeurotic fibroma

作　　者：霍媛媛[1] 张玉[1] 张桃桃[1] Huo Yuanyuan;Zhang Yu;Zhang Taotao(Department of Pathology,Yan＇an People ＇ s Hospital,Shaanxi Yan＇an 716000,China.)

机构地区：[1]延安市人民医院病理科,陕西延安716000

出　　处：《现代肿瘤医学》2018年第18期2942-2944,共3页Journal of Modern Oncology

摘　　要：目的:探讨钙化性腱膜纤维瘤(CAF)临床病理特点、免疫组化、病理诊断与鉴别诊断要点。方法:分析2例CAF临床病理特点、免疫组化、治疗与预后并复习相关文献。结果:CFA好发于青少年手掌和足底。肿瘤多<3 cm,界不清;切面呈灰白色,质硬。镜下可见增生的纤维母细胞、散在分布的钙化小灶及软骨小岛。免疫组化:vimentin(+),SMA(+),CD68(+),CD99(+)。结论:CAF是一种少见的良性软组织肿瘤,其诊断需要结合临床病理形态学特点及免疫组化,且还需与腱鞘巨细胞瘤、软骨母细胞瘤、肿瘤样钙盐沉着症、掌跖纤维瘤病、婴儿型纤维瘤病、婴儿纤维性错构瘤、软组织软骨瘤、单相纤维型滑膜肉瘤鉴别。Objective： To investigate the clinicopathological features,immunohistochemistry,pathological diagnosis and differential diagnosis of calcified aponeurotic fibroids（ CAF）.Methods： Analyze 2 cases of CAF clinical pathological features,immunohistochemistry,treatment,prognosis and review related literature.Results： CAF most commonly occurred in the palms and the soles of the feet of the teenagers.Most tumors were less than 3 cm,the edge was ill-defined,the areas of tumors had a solid pale-gray on cut surface.The proliferating fibroblasts,diffused distributed chondrioid cells and calcific debris can be seen through the microscope.Immunohistochemistry： vimentin（ ＋）,SMA（ ＋）,CD68（ ＋）,CD99（ ＋）.Conclusion： CAF is a rare benign soft tissue tumor,its diagnosis needs combining with the clinical pathology features and immunohistochemistry,and still need to be distinguished from ganglion cell tumor,chondroblastoma,tumor-like calcium salts,fibroid disease of the hand,infant fibromatosis,fibrous hamartoma of infants,chondroma of soft tissue,single phase fibrous synovial sarcoma.

关 键 词：钙化性腱膜纤维瘤 临床病理 免疫组化 鉴别诊断 

分 类 号：R739.9[医药卫生—肿瘤]