中医药调控肠黏膜屏障损伤研究概述  

Summary of research on traditional Chinese medicine in the regulation of intestinal mucosal barrier injury

作　　者：陈婷[1] 唐旭东[1] 王凤云[1] 卞立群[1] 张北华[1] CHEN Ting;TANG Xudong;WANG Fengyun(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院消化科,北京100091

出　　处：《环球中医药》2018年第8期1321-1324,共4页Global Traditional Chinese Medicine

基　　金：国家"十二五"科技支撑计划(2013BAI02B05);国家自然科学基金(81704070)

摘　　要：肠黏膜屏障在维持人体与外环境的稳态上发挥着至关重要的作用。肠黏膜屏障损伤与肠上皮细胞间紧密连接结构破坏、肠道微生物群系紊乱及肠道免疫异常活化等因素密切相关。因其发病机制尚未完全阐明,现代医学对其治疗尚存在一定的局限性。前期研究已证实一些中药复方和单体可在一定程度上改善多种诱因所致的肠黏膜屏障损伤,尤以对机械屏障、生物屏障与免疫屏障的调控作用最为显著。本文主要以肠黏膜机械屏障、生物屏障及免疫屏障为切入点,梳理了中医药调控肠黏膜屏障损伤的现状,并对其未来发展趋势进行探究。The intestinal mucosal bamer plays an important role in maintaining the homeostasis of the human bo@ and external environments. The injury of intestinal mucosal baMer is closely related to the disorganization of tight junctions between intestinal epithelial cells, the disoMer of intestinal microflora, the over-activation of intestinal immune, et al. Modem medicine has some limitations on the treatment of intestinal mucosal injury because of its complex pathogenesis. Previous researches have shown that some Chinese herb compounds and monomers can alleviate the injury of intestinal mucosal baMer, especially in the mechanical barrier, the biological baMer and the immunological baMer. The paper summarized the current situation of TCM in regulating the injury of intestinal mucosa barrier and explores its tuture development trend of treatment.

关 键 词：中医药 肠黏膜屏障 现状 发展趋势 

分 类 号：R572.3[医药卫生—消化系统]